Zürcher Höhenklinik Davos, Klinikstrasse, CH-7272 Davos Clavadel, Switzerland.
Respir Med. 2010 Jun;104(6):788-93. doi: 10.1016/j.rmed.2009.12.011. Epub 2010 Jan 15.
Monitoring of asthma control can be performed with different means including measurement of the concentration of nitric oxide (NO) in exhaled air. Due to its action on the NO-metabolism; we hypothesized that the intake of Sildenafil might augment and falsify the NO-values in exhaled air of subjects taking the drug to treat erectile dysfunction. This randomised, placebo-controlled cross-over study including 10 male non-asthmatic volunteers taking a single dose of 50 mg Sildenafil did not confirm this assumption in non-asthmatic subjects. We cannot think of any reason why asthmatics should behave differently. On the basis of these results, it does not seem necessary to ask asthma patients with elevated NO-values if they had taken any selective inhibitor of the cGMP-specific phosphodiesterase Type 5 as Sildenafil prior to the test.
哮喘控制的监测可以通过不同的方法进行，包括测量呼出气中一氧化氮（NO）的浓度。由于它对 NO 代谢的作用；我们假设西地那非的摄入可能会增加并伪造服用药物治疗勃起功能障碍的受试者呼出气中的 NO 值。这项随机、安慰剂对照的交叉研究包括 10 名服用 50 毫克西地那非单剂量的非哮喘男性志愿者，并没有在非哮喘受试者中证实这一假设。我们想不出任何理由为什么哮喘患者的表现会有所不同。基于这些结果，似乎没有必要在测试前询问呼出气中一氧化氮水平升高的哮喘患者是否服用过西地那非等 cGMP 特异性磷酸二酯酶 5 的选择性抑制剂。
