在子宫腺肌病中 p21 激活激酶表达增加。
Increased expression of p21-activated kinase in adenomyosis.
机构信息
Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
出版信息
Fertil Steril. 2010 Aug;94(3):1125-8. doi: 10.1016/j.fertnstert.2009.11.048. Epub 2010 Jan 15.
The present study was designed to evaluate whether the expression of p21-activated kinase 1 (Pak1), which recently has been shown to be increased in the eutopic endometrium of women with endometriosis, is also increased in adenomyotic nodules as well as in the eutopic endometrium in women with adenomyosis. Comparative immunohistochemical study using a monoclonal antihuman Pak1 antibody revealed that the expression of Pak1 is increased in the eutopic endometrium of women with adenomyosis during the secretory phase, along with its increased expression in adenomyotic nodules, suggesting a possible role of Pak1 in the establishment of adenomyosis.
本研究旨在评估 p21 激活激酶 1（Pak1）的表达情况，最近有研究表明其在子宫内膜异位症患者的在位内膜中增加，在子宫腺肌病患者的腺肌瘤以及在位内膜中是否也增加。使用单克隆抗人 Pak1 抗体进行的比较免疫组织化学研究表明，在分泌期，患有子宫腺肌病的妇女的在位子宫内膜中 Pak1 的表达增加，同时腺肌瘤中的表达也增加，提示 Pak1 可能在子宫腺肌病的发生中起作用。
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