Nuffield Department of Clinical Medicine, Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom.
Curr Opin Immunol. 2010 Feb;22(1):81-8. doi: 10.1016/j.coi.2009.12.008. Epub 2010 Jan 14.
It is well established that different populations of alphabeta T lymphocytes can recognize not only peptides in the context of MHC class I and class II molecules, but also foreign and self-lipids in association with CD1 proteins, which share structural similarities with MHC class I molecules. CD1 molecules are comprised of five isoforms, known as group 1 (CD1a, b, c, e) and group 2 (CD1d) CD1, presenting lipid antigens to conventional T lymphocytes or innate-like T cells bearing an invariant T cell receptor (TCR) and known as invariant NKT (iNKT) cells. During the last couple of years, several papers have been published describing important aspects of the mechanisms controlling the processing and presentation of endogenous and exogenous CD1 lipid antigens, which will be the main focus of this review.
已经证实，不同群体的αβ T 淋巴细胞不仅可以识别 MHC Ⅰ类和Ⅱ类分子背景下的肽，还可以识别与 CD1 蛋白结合的外来和自身脂质，CD1 蛋白与 MHC Ⅰ类分子具有结构相似性。CD1 分子由五个同工型组成，称为第 1 组（CD1a、b、c、e）和第 2 组（CD1d）。CD1 分子将脂质抗原呈递给常规 T 淋巴细胞或具有不变 T 细胞受体（TCR）的先天样 T 细胞，这些细胞被称为不变自然杀伤 T（iNKT）细胞。在过去的几年中，已经发表了几篇描述控制内源性和外源性 CD1 脂质抗原加工和呈递的机制的重要方面的论文，这将是本综述的主要重点。
