缺血/再灌注损伤中的心脏保护：聚焦于鞘氨醇-1-磷酸和缓激肽信号转导。
Cardioprotection in ischemia/reperfusion injury: spotlight on sphingosine-1-phosphate and bradykinin signalling.
机构信息
Victoria Hospital, Cardiology, Hayfield Road, Kirkcaldy, Fife KY2 5AH, UK.
出版信息
Prog Biophys Mol Biol. 2010 Sep;103(1):142-7. doi: 10.1016/j.pbiomolbio.2010.01.001. Epub 2010 Jan 18.
Abstract
Complex signal-transduction cascades are known to be involved in regulating cardiomyocyte function, death and survival during acute cardiac ischemia-reperfusion process, but detailed survival signalling pathways are not clear. This review presents and discusses the recent findings bearing upon the evidence on the cardioprotective effect of sphingosine-1-phosphate (S1P) and bradykinin in acute cardiac ischemia-reperfusion and underlying signalling mechanisms, particularly, through activation of P21 activated kinase.
摘要
复杂的信号转导级联被认为参与调节心肌细胞在急性心脏缺血再灌注过程中的功能、死亡和存活，但详细的存活信号通路尚不清楚。本综述介绍并讨论了最近的发现，这些发现涉及到在急性心脏缺血再灌注中鞘氨醇-1-磷酸（S1P）和缓激肽的心脏保护作用及其潜在信号机制的证据，特别是通过激活 P21 激活激酶。
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