“声功能”分子的新进展：通过超声处理与 DNA 结合。

New development of 'sono-functional' molecule: binding to DNA by sonication.

机构信息

Department of Chemistry, Shiga University of Medical Science, Seta, Otsu, Shiga 520-2192, Japan.

出版信息

Ultrason Sonochem. 2010 Apr;17(4):633-6. doi: 10.1016/j.ultsonch.2009.12.018. Epub 2009 Dec 28.

DOI:10.1016/j.ultsonch.2009.12.018

PMID:20080428

Abstract

'Sono-functional' molecule 1 was prepared and its binding properties to DNA under ultrasonic irradiation were studied by UV spectra. As a result, it was shown that the binding of 1 to DNA was enhanced by ultrasound. Being compared with its precursor 2, it is clear that terminal thiol groups of 1 play an important role in specific binding to DNA.

摘要

“多功能”分子 1 被制备出来，并通过紫外光谱研究了其在超声辐射下与 DNA 的结合性质。结果表明，超声增强了 1 与 DNA 的结合。与前体 2 相比，可以清楚地看出 1 末端的巯基在与 DNA 的特异性结合中起着重要作用。