Department of Immunochemistry, Research Institute for Microbial Diseases and WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.
Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):866-71. doi: 10.1073/pnas.0913351107. Epub 2009 Dec 22.
Varicella-zoster virus (VZV) and herpes simplex virus (HSV) are prevalent neurotropic herpesviruses that cause various nervous system diseases. Similar to other enveloped viruses, membrane fusion is an essential process for viral entry. Therefore, identification of host molecules that mediate membrane fusion is important to understand the mechanism of viral infection. Here, we demonstrate that myelin-associated glycoprotein (MAG), mainly distributed in neural tissues, associates with VZV glycoprotein B (gB) and promotes cell-cell fusion when coexpressed with VZV gB and gH/gL. VZV preferentially infected MAG-transfected oligodendroglial cells. MAG also associated with HSV-1 gB and enhanced HSV-1 infection of promyelocytes. These findings suggested that MAG is involved in VZV and HSV infection of neural tissues.
水痘带状疱疹病毒（VZV）和单纯疱疹病毒（HSV）是流行的嗜神经疱疹病毒，可引起各种神经系统疾病。与其他包膜病毒类似，膜融合是病毒进入的必需过程。因此，鉴定介导膜融合的宿主分子对于理解病毒感染的机制非常重要。在这里，我们证明少突胶质细胞髓鞘相关糖蛋白（MAG）主要分布在神经组织中，与 VZV 糖蛋白 B（gB）结合，并在与 VZV gB 和 gH/gL 共表达时促进细胞-细胞融合。VZV 优先感染转染 MAG 的少突胶质细胞。MAG 还与 HSV-1 gB 结合，并增强 HSV-1 对早幼粒细胞的感染。这些发现表明 MAG 参与了 VZV 和 HSV 对神经组织的感染。
Proc Natl Acad Sci U S A. 2009-12-22
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