Cox J L, Schuessler R B, D'Agostino H J, Stone C M, Chang B C, Cain M E, Corr P B, Boineau J P
Department of Surgery, Washington University School of Medicine, Barnes Hospital, St. Louis, Mo 63110.
J Thorac Cardiovasc Surg. 1991 Apr;101(4):569-83.
On the basis of the known electrophysiologic mechanisms of atrial fibrillation, multiple surgical procedures were designed and tested in dogs to determine the feasibility of developing a surgical cure for human atrial fibrillation. These experimental studies culminated in a surgical approach that effectively creates an electrical maze in the atrium. The atrial incisions prevent atrial reentry and allow sinus impulses to activate the entire atrial myocardium, thereby preserving atrial transport function postoperatively. Since September 1987, this surgical procedure has been applied in seven patients, five with paroxysmal atrial fibrillation of 2 to 9 years' duration and two with chronic atrial fibrillation of 3 and 10 years' duration. All seven patients have been cured of atrial fibrillation and none is receiving any postoperative antiarrhythmic medications.
基于已知的心房颤动电生理机制，设计并在犬类身上测试了多种外科手术方法，以确定开发一种治疗人类心房颤动的手术方法的可行性。这些实验研究最终形成了一种手术方法，该方法能有效地在心房中形成一个电迷宫。心房切口可防止心房折返，并使窦房结冲动激活整个心房心肌，从而在术后保留心房的运输功能。自1987年9月以来，该手术已应用于7例患者，其中5例为病程2至9年的阵发性心房颤动，2例为病程3年和10年的慢性心房颤动。所有7例患者的心房颤动均已治愈，术后均未服用任何抗心律失常药物。
