Guo X, Tang X C
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai.
Life Sci. 1991;48(14):1365-70. doi: 10.1016/0024-3205(91)90432-b.
The effects of lappaconitine (LA) and N-deacetyllappaconitine (DLA) on footshock-induced analgesia (FSIA) were studied by the rat tail flick test. Rats subjected to 90 s nonescaping footshock had a significant increase in tail flick latency. Naloxone (4 micrograms, i.c.v.) partially antagonized the FSIA. After 5 consecutive exposures to footshock, rats developed a complete tolerance to the FSIA. The rats tolerant to FSIA showed a cross-tolerance to morphine- but not LA- and DLA-induced analgesia. Administrations of subanalgesic doses of LA and DLA potentiated the FSIA in both intact and adrenalectomized rats.
通过大鼠甩尾试验研究了去甲乌药碱（LA）和去乙酰基去甲乌药碱（DLA）对足部电击所致镇痛（FSIA）的影响。遭受90秒不可逃避足部电击的大鼠甩尾潜伏期显著延长。纳洛酮（4微克，脑室内注射）部分拮抗了FSIA。连续5次暴露于足部电击后，大鼠对FSIA产生了完全耐受性。对FSIA耐受的大鼠对吗啡诱导的镇痛表现出交叉耐受性，但对LA和DLA诱导的镇痛没有交叉耐受性。给予亚镇痛剂量的LA和DLA可增强完整大鼠和肾上腺切除大鼠的FSIA。
