母亲被动吸烟与唇裂伴或不伴腭裂的风险。
Maternal passive smoking and risk of cleft lip with or without cleft palate.
机构信息
Institute of Reproductive and Child Health, Peking University Health Science Center, Beijing, People's Republic of China.
出版信息
Epidemiology. 2010 Mar;21(2):240-2. doi: 10.1097/EDE.0b013e3181c9f941.
BACKGROUND
Maternal smoking has been consistently associated with increased risk of cleft lip with or without cleft palate (CL/P). Few studies have explored the possible effect of passive smoking. We examined the association between maternal passive smoking and the risk of CL/P among nonsmoking women in China.
METHODS
Subjects included 88 infants with CL/P and 651 infants with no major external birth defects. Data were collected by trained health workers through face-to-face interviews.
RESULTS
The odds ratio (OR) for CL/P associated with maternal passive smoking was 1.8 (95% confidence interval = 1.1-2.8). After adjustment for maternal occupation, periconceptional flu or fever, and infant sex, the risk was 2.0 (1.2-3.4). The adjusted ORs for exposure levels of 1-6 times per week and more than 6 times per week (at least 1 cigarette each time) were 1.6 (0.9-2.9) and 2.8 (1.5-5.2), respectively.
CONCLUSION
Maternal passive smoking during pregnancy was associated with an increased risk for CL/P in offspring.
背景
母亲吸烟与唇裂伴或不伴腭裂（CL/P）的风险增加有关。很少有研究探讨被动吸烟的可能影响。我们研究了中国不吸烟妇女中母亲被动吸烟与 CL/P 风险之间的关系。
方法
研究对象包括 88 例唇裂伴腭裂婴儿和 651 例无主要外部出生缺陷的婴儿。数据由经过培训的卫生工作者通过面对面访谈收集。
结果
母亲被动吸烟与 CL/P 相关的比值比（OR）为 1.8（95%置信区间=1.1-2.8）。在校正母亲职业、围孕期流感或发热以及婴儿性别后，风险为 2.0（1.2-3.4）。每周暴露 1-6 次和每周暴露超过 6 次（每次至少 1 支烟）的调整后 OR 分别为 1.6（0.9-2.9）和 2.8（1.5-5.2）。
结论
母亲在怀孕期间被动吸烟与后代发生 CL/P 的风险增加有关。
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