Institute of Reproductive and Child Health, Peking University Health Science Center, Beijing, People's Republic of China.
Epidemiology. 2010 Mar;21(2):240-2. doi: 10.1097/EDE.0b013e3181c9f941.
Maternal smoking has been consistently associated with increased risk of cleft lip with or without cleft palate (CL/P). Few studies have explored the possible effect of passive smoking. We examined the association between maternal passive smoking and the risk of CL/P among nonsmoking women in China.
Subjects included 88 infants with CL/P and 651 infants with no major external birth defects. Data were collected by trained health workers through face-to-face interviews.
The odds ratio (OR) for CL/P associated with maternal passive smoking was 1.8 (95% confidence interval = 1.1-2.8). After adjustment for maternal occupation, periconceptional flu or fever, and infant sex, the risk was 2.0 (1.2-3.4). The adjusted ORs for exposure levels of 1-6 times per week and more than 6 times per week (at least 1 cigarette each time) were 1.6 (0.9-2.9) and 2.8 (1.5-5.2), respectively.
Maternal passive smoking during pregnancy was associated with an increased risk for CL/P in offspring.
母亲吸烟与唇裂伴或不伴腭裂（CL/P）的风险增加有关。很少有研究探讨被动吸烟的可能影响。我们研究了中国不吸烟妇女中母亲被动吸烟与 CL/P 风险之间的关系。
研究对象包括 88 例唇裂伴腭裂婴儿和 651 例无主要外部出生缺陷的婴儿。数据由经过培训的卫生工作者通过面对面访谈收集。
母亲被动吸烟与 CL/P 相关的比值比（OR）为 1.8（95%置信区间=1.1-2.8）。在校正母亲职业、围孕期流感或发热以及婴儿性别后，风险为 2.0（1.2-3.4）。每周暴露 1-6 次和每周暴露超过 6 次（每次至少 1 支烟）的调整后 OR 分别为 1.6（0.9-2.9）和 2.8（1.5-5.2）。
母亲在怀孕期间被动吸烟与后代发生 CL/P 的风险增加有关。
