Unit on the Genetic Basis of Mood & Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.
Nat Genet. 2010 Feb;42(2):128-31. doi: 10.1038/ng.523. Epub 2010 Jan 17.
The major mood disorders, which include bipolar disorder and major depressive disorder (MDD), are considered heritable traits, although previous genetic association studies have had limited success in robustly identifying risk loci. We performed a meta-analysis of five case-control cohorts for major mood disorder, including over 13,600 individuals genotyped on high-density SNP arrays. We identified SNPs at 3p21.1 associated with major mood disorders (rs2251219, P = 3.63 x 10(-8); odds ratio = 0.87; 95% confidence interval, 0.83-0.92), with supportive evidence for association observed in two out of three independent replication cohorts. These results provide an example of a shared genetic susceptibility locus for bipolar disorder and MDD.
主要心境障碍，包括双相情感障碍和重度抑郁症（MDD），被认为是遗传特征，尽管先前的遗传关联研究在稳健地识别风险基因座方面取得的成功有限。我们对五个主要心境障碍病例对照队列进行了荟萃分析，包括超过 13600 名在高密度 SNP 芯片上进行基因分型的个体。我们在 3p21.1 上鉴定出与主要心境障碍相关的 SNP（rs2251219，P=3.63x10(-8)；优势比=0.87；95%置信区间，0.83-0.92），在三个独立的复制队列中有两个队列观察到关联的支持证据。这些结果提供了一个双相情感障碍和 MDD 共享遗传易感性基因座的例子。
