Therapeutics Research, FibroGen, Inc., San Francisco, California 94080, USA.
J Invest Dermatol. 2010 Feb;130(2):338-41. doi: 10.1038/jid.2009.331.
The roles of connective tissue growth factor (CTGF) and transforming growth factor-beta (TGF-beta), both well-known collagen production stimulators, were examined in skin aging. Aged skin and fibroblasts exhibited a coordinate decrease in CTGF, TGF-beta, and type I procollagen expression and content. CTGF knockdown and TGF-beta blockade in normal dermal fibroblasts reduced procollagen expression, whereas overexpressing CTGF increased procollagen by a TGF-beta/Smad signaling-dependent mechanism without involving Smad2/3.
结缔组织生长因子 (CTGF) 和转化生长因子-β (TGF-β) 都是众所周知的胶原蛋白产生刺激因子，本研究探讨了它们在皮肤衰老中的作用。衰老皮肤和成纤维细胞表现出 CTGF、TGF-β 和 I 型前胶原表达和含量的协同下降。在正常真皮成纤维细胞中敲低 CTGF 和阻断 TGF-β 会减少前胶原的表达，而 CTGF 的过表达则通过 TGF-β/Smad 信号依赖性机制增加前胶原的表达，而不涉及 Smad2/3。
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