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利用来自sp. T65的生物活性材料与合成介孔二氧化硅颗粒SBA-15开发多功能美容霜。

Development of Multifunctional Cosmetic Cream Using Bioactive Materials from sp. T65 with Synthesized Mesoporous Silica Particles SBA-15.

作者信息

Dahal Ram Hari, Nguyen Tuan Manh, Shim Dong Seop, Kim Joon Young, Lee Jangyul, Kim Jaisoo

机构信息

Department of Life Science, College of Natural Sciences, Kyonggi University, Suwon, Gyeonggi-Do 16227, Korea.

Institute of Life Sciences, Thai Nguyen University of Agriculture and Forestry, Quyet Thang, Thai Nguyen 250-000, Vietnam.

出版信息

Antioxidants (Basel). 2020 Mar 26;9(4):278. doi: 10.3390/antiox9040278.

DOI:10.3390/antiox9040278
PMID:32224894
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7222176/
Abstract

Various cosmetics having a single function are increasingly being used, but cosmetics having multifunctional activities remain limited. We aimed to develop a multifunctional cosmetic cream having antioxidant, anti-tyrosinase, anti-aging and antimicrobial activities. Antimicrobial activities were performed by disc-diffusion method. Cell toxicity and cell proliferations were evaluated in a 96-well plate with different cell lines such as HaCaT, RAW264.7, CCD-986Sk, B16F1, and B16F10. Mushroom tyrosinase inhibition, elastase inhibition, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities were evaluated and IC was calculated. Mesoporous silica particle was synthesized using Pluronic P123 and tetraethyl ortho-silicate (TEOS). Facial pictures were captured by VISIA-CR (Facial Imaging System for Clinical Research). Roughness of image was analysed by PRIMOS software and brightness of image was analyzed by Chromameter CR-400. The crude product of strain T65 inhibited the different human pathogenic bacteria such as Bacillus subtilis, Escherichia coli, Propionibacterium acnes, Staphylococcus aureus, Pseudomonas aeruginosa, and Staphylococcus epidermidis. The IC of T65 crude product for mushroom tyrosinase, elastase, and DPPH radical scavenging activities were 58.73, 14.68, and 6.31 µg/mL, respectively. T65 crude product proliferated collagen type I in CCD-986Sk cell up to 145.91% ± 9.11% (mean ± SD; mean of 24, 48, and 72 h) at 250 pg/mL. Synthesized mesoporous particles (SBA-15) confirmed the sustainable performance by control-release for three days. Formulated functional cosmetic cream containing T65 embedded SBA-15, significantly decreased the skin roughness by 4.670% and increased the skin brightness by 0.472% after application of 4 weeks. T65 crude product inhibited both Gram-positive and Gram-negative pathogens. Synthesized mesoporous particle, SBA-15, confirmed the physiologically active substance was released in sustainable release condition. T65 crude product showed impeccable antimicrobial, antioxidant, anti-aging, and whitening activities with non-cytotoxic effects to different cell lines related to the human skin.

摘要

具有单一功能的各类化妆品正越来越多地被使用，但具有多种功能的化妆品仍然有限。我们旨在开发一种具有抗氧化、抗酪氨酸酶、抗老化和抗菌活性的多功能美容霜。抗菌活性通过纸片扩散法进行测定。在96孔板中使用不同的细胞系（如HaCaT、RAW264.7、CCD - 986Sk、B16F1和B16F10）评估细胞毒性和细胞增殖情况。评估了蘑菇酪氨酸酶抑制、弹性蛋白酶抑制以及1,1 - 二苯基 - 2 - 苦基肼（DPPH）自由基清除活性，并计算了半数抑制浓度（IC）。使用普朗尼克P123和正硅酸四乙酯（TEOS）合成了介孔二氧化硅颗粒。通过VISIA - CR（临床研究面部成像系统）拍摄面部照片。使用PRIMOS软件分析图像粗糙度，使用色差仪CR - 400分析图像亮度。菌株T65的粗产物对不同的人类病原菌如枯草芽孢杆菌、大肠杆菌、痤疮丙酸杆菌、金黄色葡萄球菌、铜绿假单胞菌和表皮葡萄球菌具有抑制作用。T65粗产物对蘑菇酪氨酸酶、弹性蛋白酶和DPPH自由基清除活性的半数抑制浓度分别为58.73、14.68和6.31μg/mL。T65粗产物在250 pg/mL时使CCD - 986Sk细胞中的I型胶原蛋白增殖至145.91%±9.11%（平均值±标准差；24、48和72小时的平均值）。合成的介孔颗粒（SBA - 15）通过三天的控释证实了其可持续性能。含有包埋T65的SBA - 15的配方功能性美容霜在应用4周后显著降低皮肤粗糙度4.670%，并提高皮肤亮度0.472%。T65粗产物对革兰氏阳性和革兰氏阴性病原菌均有抑制作用。合成的介孔颗粒SBA - 15证实生理活性物质在可持续释放条件下释放。T65粗产物对与人类皮肤相关的不同细胞系显示出无可挑剔的抗菌、抗氧化、抗老化和美白活性且无细胞毒性作用。

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