Department of Radiology, Sant'Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.
Radiol Med. 2010 Apr;115(3):442-52. doi: 10.1007/s11547-010-0502-7. Epub 2010 Jan 15.
This study was performed to describe the possible presence of extrapancreatic neoplasms in patients with intraductal papillary mucinous neoplasm (IPMN) and to evaluate whether the extrapancreatic tumours were synchronous or metachronous to IPMNs.
One hundred and forty-two patients (56 men and 86 women; mean age 69.5 years, range 37-98) with IPMN diagnosed using the Sendai criteria were enrolled. Six patients (4.2%) had type I, 103 (72.5%) type II and 33 (23.2%) type III IPMN. All patients were studied using the following imaging techniques: ultrasonography (US), multidetector computed tomography (MDCT) and magnetic resonance cholangiopancreatography (MRCP).
Pancreatic IPMN was localised in the head in 43 patients (30.3%), in the body in 13 (9.2%), in the tail in ten (7.0%), in the head-body in 17 (12.0%), in the body-tail in 15 (10.6%) diffuse throughout the gland in 44 (31.0%). The mean size of the cystic lesions was [(mean+/-standard deviation (SD)] 1.9+/-1.9 cm (range 0.5-8.0 cm). Twenty patients (14.1%) had associated pancreatic or extrapancreatic diseases. In evaluating the distribution of pancreatic or extrapancreatic diseases according to IPMN type, we found that this was not significantly different among types I, II and III (p=0.776).
The majority of pancreatic and extrapancreatic cancers occur before the diagnosis of IPMNs is made and is not related to the type of IPMN.
本研究旨在描述胰内导管乳头状黏液性肿瘤（IPMN）患者中可能存在的胰外肿瘤，并评估胰外肿瘤与 IPMN 是同时发生还是异时发生。
本研究纳入了 142 例经仙台标准诊断为 IPMN 的患者（56 名男性和 86 名女性；平均年龄 69.5 岁，范围 37-98 岁）。其中 6 例（4.2%）为 I 型，103 例（72.5%）为 II 型，33 例（23.2%）为 III 型。所有患者均采用以下影像学技术进行研究：超声检查（US）、多排螺旋 CT（MDCT）和磁共振胰胆管成像（MRCP）。
胰头 43 例（30.3%）、胰体 13 例（9.2%）、胰尾 10 例（7.0%）、胰头-胰体 17 例（12.0%）、胰体-胰尾 15 例（10.6%）、全胰弥漫性 44 例（31.0%）。囊性病变的平均大小为[（均数+/-标准差（SD）]1.9+/-1.9cm（范围 0.5-8.0cm）。20 例（14.1%）患者同时患有胰腺或胰外疾病。根据 IPMN 类型评估胰腺或胰外疾病的分布，我们发现 I 型、II 型和 III 型之间无显著差异（p=0.776）。
大多数胰腺和胰外癌症在诊断 IPMN 之前发生，与 IPMN 类型无关。
