State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China.
Int J Biol Markers. 2009 Oct-Dec;24(4):258-64. doi: 10.1177/172460080902400407.
The aim of this longitudinal study was to try and improve the specificity of carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 in monitoring tumor recurrence in patients with resectable gastric adenocarcinoma by setting suitable elevation levels.
One hundred eighty-one patients with resectable gastric adenocarcinoma were considered. Serum samples were obtained preoperatively and every 3 months postoperatively.
Preoperative CEA and CA19-9 positivity rates were 19.9% and 18.2%. The specificity and sensitivity of CEA elevation to monitor recurrence were 92.9% and 23.4% versus 76.5% and 78.9% in CEA-negative versus CEA-positive patients, respectively. For CA19-9 the specificity and sensitivity were 95.0% and 18.8% versus 60.0% and 83.3% in CA19-9-negative versus CA19-9-positive patients, respectively. When we set the elevation level of CEA at 5 ng/mL, the specificity of CEA elevation to monitor recurrence increased to 94.1% for CEA-positive patients. The specificity increased to 93.3% for CA19-9-positive patients when the CA19-9 elevation level was set at 100 U/mL.
For CEA- or CA19-9-positive patients with resectable gastric adenocarcinoma we can increase the specificity of CEA and CA19-9 by setting the elevation level of CEA at 5 ng/mL and CA19-9 at 100 U/mL.
本纵向研究旨在通过设定合适的升高水平，尝试提高癌胚抗原（CEA）和糖类抗原（CA）19-9 在监测可切除胃腺癌患者肿瘤复发时的特异性。
纳入 181 例可切除胃腺癌患者。术前和术后每 3 个月采集血清样本。
术前 CEA 和 CA19-9 阳性率分别为 19.9%和 18.2%。CEA 升高对监测复发的特异性和敏感性分别为 92.9%和 23.4%，与 CEA 阴性与 CEA 阳性患者相比；CA19-9 的特异性和敏感性分别为 95.0%和 18.8%，与 CA19-9 阴性与 CA19-9 阳性患者相比。当我们将 CEA 的升高水平设定为 5ng/ml 时，CEA 升高对监测复发的特异性在 CEA 阳性患者中增加到 94.1%。当将 CA19-9 的升高水平设定为 100U/ml 时，CA19-9 阳性患者的特异性增加到 93.3%。
对于可切除胃腺癌的 CEA 或 CA19-9 阳性患者，我们可以通过将 CEA 的升高水平设定为 5ng/ml 和 CA19-9 设定为 100U/ml 来提高 CEA 和 CA19-9 的特异性。
