Division of Digestive Surgery, Xijing Hospital of Digestive Diseases, the Fourth Military Medical University, 127 West Changle Road, 710032, , Xian, Shaanxi, China.
Department of Dermatology, Xijing Hospital, the Fourth Military Medical University, 127 West Changle Road, 710032, , Xian, Shaanxi, China.
BMC Cancer. 2017 Nov 9;17(1):737. doi: 10.1186/s12885-017-3738-y.
The diagnostic and prognostic significance of carcinoembryonic antigen (CEA), carbohydrate associated antigen 19-9 (CA19-9), alpha-fetoprotein (AFP) and cancer antigen 125 (CA125) in early gastric cancer have not been investigated yet. Thus, the present study aimed to explore the diagnostic and prognostic significance of the four tumor markers for early gastric cancer.
From September 2008 to March 2015, 587 early gastric cancer patients were given radical gastrectomy in our center. The clinicopathological characteristics were recorded. The association between levels of CEA and CA19-9 and clinicopathological characteristics and prognosis of patients were analyzed.
There were 444 men (75.6%) and 143 women (24.4%). The median age was 57 years (ranged 21-85). The 1-, 3- and 5-year overall survival rate was 99.1%, 96.8% and 93.1%, respectively. The positive rate of CEA, CA19-9, AFP and CA125 was 4.3%, 4.8%, 1.5% and 1.9%, respectively. The positive rate of all markers combined was 10.4%. The associations between the clinicopathological features and levels of CEA and CA19-9 were analyzed. No significant association was found between CEA level and clinicopathological features. However, elevated CA19-9 level was correlated with female gender and presence of lymph node metastasis. Age > 60 years old, presence of lymph node metastasis and elevation of CEA level were independent risk factors for poor prognosis of early gastric cancer.
The positive rates of CEA, CA19-9, APF and CA125 were relatively low for early gastric cancer. Elevation of CA19-9 level was associated with female gender and presence of lymph node metastasis. Elevation of CEA level was an independent risk factor for the poor prognosis of early gastric cancer.
癌胚抗原（CEA）、糖类抗原 19-9（CA19-9）、甲胎蛋白（AFP）和癌抗原 125（CA125）在早期胃癌中的诊断和预后意义尚未得到研究。因此，本研究旨在探讨这四种肿瘤标志物对早期胃癌的诊断和预后意义。
2008 年 9 月至 2015 年 3 月，我院对 587 例早期胃癌患者行根治性胃切除术，记录其临床病理特征。分析 CEA 和 CA19-9 水平与患者临床病理特征及预后的关系。
587 例患者中，男 444 例（75.6%），女 143 例（24.4%）；年龄 21~85 岁，中位年龄 57 岁；1、3、5 年总生存率分别为 99.1%、96.8%和 93.1%。CEA、CA19-9、AFP 和 CA125 的阳性率分别为 4.3%、4.8%、1.5%和 1.9%，四项联合的阳性率为 10.4%。分析 CEA 和 CA19-9 水平与临床病理特征的关系。CEA 水平与临床病理特征无明显相关性，而 CA19-9 水平与女性和淋巴结转移有关。年龄>60 岁、淋巴结转移和 CEA 水平升高是早期胃癌预后不良的独立危险因素。
CEA、CA19-9、AFP 和 CA125 对早期胃癌的阳性率相对较低。CA19-9 水平升高与女性和淋巴结转移有关。CEA 水平升高是早期胃癌预后不良的独立危险因素。
Zotero 插件
