Research Center of Gastroenterology and Liver Disease. Shaheed Beheshti University, M.C. Tehran, Iran.
Rev Esp Enferm Dig. 2009 Dec;101(12):850-4. doi: 10.4321/s1130-01082009001200004.
we assessed the prevalence, the related symptoms, and the endoscopic and histologic gastric features of celiac disease (CD) in patients with Helicobacter pylori (Hp).
450 dyspeptic patients were studied. Biopsies of gastric antrum and duodenum, CD serology, and total IgA were obtained. Histological findings were scored with the Marsh-Rostami criteria.
411 (91.3%) patients were Hp positive. Duodenal histology was normal in 385 (85.6%) patients, 124 (27.5%) had duodenitis and 28 (6.2%) showed duodenal abnormalities (Marsh I-IIIc). Twenty three/28 (82.1%) patients with malabsorption pattern were also Hp positive. Serological analysis: 12 of 31 (38.7%) positive patients had abnormal histology (Marsh I,-IIIc). Nine out 450 patients were IgA deficient; none of them was serologically positive for CD.
although a high prevalence of Hp infection was found in this study, the relationship between Hp infection and CD was similar to that reported in other geographic areas.
我们评估了幽门螺杆菌（Hp）感染患者中乳糜泻（CD）的患病率、相关症状以及内镜和组织学胃特征。
研究了 450 例消化不良患者。获取了胃窦和十二指肠活检、CD 血清学和总 IgA。采用 Marsh-Rostami 标准对组织学发现进行评分。
411 例（91.3%）患者 Hp 阳性。385 例（85.6%）患者十二指肠组织学正常，124 例（27.5%）有十二指肠炎，28 例（6.2%）显示十二指肠异常（Marsh I-IIIc）。23/28（82.1%）有吸收不良模式的患者也 Hp 阳性。血清学分析：31 例阳性患者中有 12 例（38.7%）组织学异常（Marsh I，-IIIc）。450 例患者中有 9 例 IgA 缺乏；他们均未血清学阳性 CD。
尽管本研究中发现 Hp 感染的患病率较高，但 Hp 感染与 CD 之间的关系与其他地理区域报道的相似。
