School of Human Kinetics, Faculty of Health Science, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada.
Climacteric. 2010 Aug;13(4):347-54. doi: 10.3109/13697130903276422.
To determine the relationships between the percentage predicted cardiorespiratory fitness (%CRF) and the anthropometric and metabolic cardiovascular disease risk factors in asymptomatic, premenopausal women.
Data are baseline values obtained in 97 healthy premenopausal women (age 49.9 +/- 1.9 years; body mass index 23.2 +/- 2.2 kg/m(2)) participating in a longitudinal study from 2004 to 2009. The outcome measures were peak oxygen consumption (VO(2) peak), body mass index, body composition (percentage fat, fat mass, fat-free mass), waist circumference, abdominal subcutaneous fat, visceral fat, resting blood pressure and fasting lipids, glucose and insulin levels.
The %CRF was negatively associated with body mass index, fat mass, percentage fat, waist circumference, abdominal subcutaneous fat, visceral fat, triglycerides, triglyceride/high density lipoprotein cholesterol, total cholesterol, total cholesterol/high density lipoprotein cholesterol, fasting insulin levels and HOMA-IR (- 0.59 < or = r < or = - 0.20; 0.01 < p < 0.05) and positively associated with insulin sensitivity index (r = 0.23; p < 0.05). VO(2) peak was associated with the same variables; however, correlations were slightly better (- 0.70 < or = r < or = 0.30; 0.01 < p < 0.05). Stepwise multiple regression analysis showed that %CRF was only independently correlated with plasma triglyceride levels.
The results of this study suggest that %CRF was not a major predictor of anthropometric and metabolic variables associated with an increased risk of cardiovascular disease in asymptomatic premenopausal women. Finally, the VO(2) peak is a better predictor than the %CRF to assess the risk of cardiovascular disease in asymptomatic premenopausal women.
确定预测心肺适能（%CRF）与无症状、绝经前女性的人体测量和代谢心血管疾病危险因素之间的关系。
本研究的数据来自于 2004 年至 2009 年期间参加一项纵向研究的 97 名健康绝经前女性（年龄 49.9±1.9 岁；体重指数 23.2±2.2kg/m2）的基线值。结果测量指标包括峰值摄氧量（VO2peak）、体重指数、身体成分（体脂百分比、脂肪量、去脂体重）、腰围、腹部皮下脂肪、内脏脂肪、静息血压和空腹血脂、血糖和胰岛素水平。
%CRF 与体重指数、脂肪量、体脂百分比、腰围、腹部皮下脂肪、内脏脂肪、甘油三酯、甘油三酯/高密度脂蛋白胆固醇、总胆固醇、总胆固醇/高密度脂蛋白胆固醇、空腹胰岛素水平和 HOMA-IR 呈负相关（-0.59≤r≤-0.20；0.01<p<0.05），与胰岛素敏感指数呈正相关（r=0.23；p<0.05）。VO2peak 与相同变量相关；然而，相关性稍好（-0.70≤r≤-0.30；0.01<p<0.05）。逐步多元回归分析显示，%CRF 仅与血浆甘油三酯水平独立相关。
本研究结果表明，%CRF 不是预测无症状绝经前女性与心血管疾病风险增加相关的人体测量和代谢变量的主要指标。最后，VO2peak 是评估无症状绝经前女性心血管疾病风险的更好指标，而不是%CRF。
