Ghasemi Nasrin, Karimi-Zarchi Mojgan, Mortazavi-Zadeh Mohammad Reza, Atash-Afza Ali
Research and Clinical Center for Infertility, Yazd Shahid Sadoughi Medical Sciences University, Safayeh, Bouali St, 8916877391, Yazd, Iran.
Cancer Genet Cytogenet. 2010 Jan 15;196(2):167-70. doi: 10.1016/j.cancergencyto.2009.09.013.
Polymorphisms of the TP53 gene codon 72 exhibit less effective function in tumor suppression and usually are associated with human cancer. To investigate the frequency of proline and arginine alleles of TP53 codon 72, the present study analyzed the DNA from blood samples of 30 Iranian women with endometrial cancer, in comparison with 32 healthy women. A Pro/Pro genotype was associated with increased endometrial cancer risk (odds ratio OR = 3.7, 95% confidence interval CI = 0.539-25.59). In patients, Pro allele frequency (68%) was higher than Arg frequency (32%), and higher also than Pro frequency in healthy control subjects (55%) (OR = 1.9, 95% CI = 0.903-3.893). It could be that the Pro allele is less apoptotic than the Arg allele, and that the Arg allele most probably activates transcription factors more efficiently than the Pro variant. These novel findings on the frequency of TP53 gene codon 72 polymorphism in endometrial cancer in Iranian women indicate that in this population the Pro allele might be associated with increased risk of endometrial cancer.
TP53基因密码子72的多态性在肿瘤抑制方面功能较弱，且通常与人类癌症相关。为了研究TP53密码子72脯氨酸和精氨酸等位基因的频率，本研究分析了30名伊朗子宫内膜癌女性血液样本中的DNA，并与32名健康女性进行比较。脯氨酸/脯氨酸（Pro/Pro）基因型与子宫内膜癌风险增加相关（优势比OR = 3.7，95%置信区间CI = 0.539 - 25.59）。在患者中，脯氨酸等位基因频率（68%）高于精氨酸频率（32%），也高于健康对照者中的脯氨酸频率（55%）（OR = 1.9，95% CI = 0.903 - 3.893）。可能是脯氨酸等位基因的凋亡能力低于精氨酸等位基因，并且精氨酸等位基因比脯氨酸变体更有可能更有效地激活转录因子。这些关于伊朗女性子宫内膜癌中TP53基因密码子72多态性频率的新发现表明，在该人群中脯氨酸等位基因可能与子宫内膜癌风险增加有关。
