Zalányi S, Németh G
Szent-Györgyi Albert Orvostudományi Egyetem, Szeged.
Orv Hetil. 1991 Mar 17;132(11):563-7.
Starting from the theory, that progesterone (P) may be one of the triggers of physiologic ovulation, P receptor blocking agent Mifepristone was administered to 7 regularly menstruating women, 2 days before the expected time of ovulation. Ovulation was monitored by ultrasound folliculometry and determination of serum estradiol (E2), P and luteinizing hormone (LH) levels. The luteal phase was checked by measuring urinary pregnandiol glucuronide excretion. Administration of the drug was properly timed in 5 cases, none of the existing follicles ruptured, one got luteinized and 4 had undergone atresia. According to these findings P seems to be a trigger of ovulatory events.
基于孕酮（P）可能是生理性排卵触发因素之一的理论，在预计排卵时间前两天，对7名月经周期规律的女性给予P受体阻断剂米非司酮。通过超声卵泡监测以及测定血清雌二醇（E2）、P和黄体生成素（LH）水平来监测排卵情况。通过测量尿孕二醇葡萄糖醛酸排泄量来检查黄体期。5例用药时间恰当，现有卵泡均未破裂，1例卵泡黄素化，4例卵泡闭锁。根据这些发现，P似乎是排卵事件的触发因素。
