School of Sport and Exercise Sciences, University of Birmingham, Birmingham, UK.
Neurosci Biobehav Rev. 2010 Sep;35(1):122-6. doi: 10.1016/j.neubiorev.2010.01.005. Epub 2010 Jan 18.
The hunt for novel tools to investigate empirical questions is ever present in psychophysiological research. Antibody response to vaccination has received increasing attention over recent years as a useful measure of in vivo immune function. There is now considerable evidence that the magnitude of the antibody response to vaccination is associated with a wide range of psychosocial factors. Further, there are preliminary indications that manipulating psychosocial variables, using both chronic and acute interventions, can also alter the efficacy of the vaccination. This review will discuss the theoretical and clinical relevance of the vaccine model in this context, and will address key methodological considerations for researchers considering adopting this approach. The review will also address how the strategic use of this model could help researchers further elucidate some of the remaining theoretical issues.
在心理生理学研究中，寻找新颖的工具来研究经验问题一直是一个热门话题。近年来，疫苗接种后的抗体反应作为一种评估体内免疫功能的有用指标受到了越来越多的关注。现在有大量证据表明，疫苗接种后的抗体反应强度与广泛的心理社会因素有关。此外，初步迹象表明，使用慢性和急性干预措施来操纵心理社会变量也可以改变疫苗接种的效果。本文将讨论在这种情况下疫苗模型的理论和临床相关性，并讨论考虑采用这种方法的研究人员的关键方法学考虑因素。本文还将讨论如何战略性地使用这种模型，以帮助研究人员进一步阐明一些剩余的理论问题。
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