Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, The Netherlands.
Eur Neuropsychopharmacol. 2010 Apr;20(4):226-35. doi: 10.1016/j.euroneuro.2009.12.003. Epub 2010 Jan 18.
Animal literature suggests an important role for histamine in memory. In humans, this hypothesis has been scarcely tested and results from studies that have addressed this are conflicting. Second, impaired memory performance may be secondary to sedation. This study aimed to determine whether a centrally active antihistamine impairs memory performance and to dissociate such effects from sedation. Eighteen healthy volunteers received single oral doses of dexchlorpheniramine 4 mg, lorazepam 1mg and placebo in a 3-way, double blind, crossover designed study. The active control lorazepam impaired episodic- and working memory performance and increased sedation, while dexchlorpheniramine only increased sedation.
动物文学提示组胺在记忆中具有重要作用。在人类中，该假说几乎未得到检验，并且解决此问题的研究结果相互矛盾。其次，记忆表现受损可能继发于镇静。本研究旨在确定中枢作用的抗组胺药是否会损害记忆表现，并将这些作用与镇静作用区分开。在一项 3 向，双盲，交叉设计的研究中，18 名健康志愿者分别口服给予氯苯那敏 4mg，劳拉西泮 1mg 和安慰剂。活性对照劳拉西泮损害情景记忆和工作记忆表现，并增加镇静作用，而氯苯那敏仅增加镇静作用。
