George Washington University Medical Center, Newborn Services, 900 23rd St NW, Suite G-2092, Washington, DC 20037, USA.
Pediatrics. 2010 Feb;125(2):e333-9. doi: 10.1542/peds.2008-3369. Epub 2010 Jan 18.
The goal was to examine the association of gender with intraventricular hemorrhage (IVH) or periventricular leukomalacia (PVL) in a large national database.
The National Inpatient Sample database was analyzed for the years 1998, 1999, 2001, 2002, and 2004 and its pediatrics version for the years 1997, 2000, and 2003. The National Inpatient Sample and its pediatrics version are annually collected databases for inpatient admissions from >1000 hospitals across the United States. We included all very low birth weight (VLBW) infants (birth weight [BW] of <1500 g) and excluded infants with major congenital anomalies. VLBW infants with IVH or PVL were identified by using International Classification of Diseases, Ninth Revision, diagnostic codes. We analyzed the data by using chi(2) and Fisher's exact tests to calculate odds ratios (ORs) and logistic regression analysis to control for possible confounders.
The data included 104 847 VLBW infants. With controlling for significant confounders, IVH was associated with male gender (15.9% vs 13.6%; adjusted OR [AOR]: 1.15 [95% confidence interval: 1.11-1.19]; P < .001). More boys than girls had severe IVH (38% vs 32.7%; AOR: 1.18 [95% confidence interval: 1.06-1.32]; P < .004). The increased rates of IVH and severe IVH in boys were significant in the BW subgroups of <1000 g and 1000 to 1499 g. The association of male gender with IVH and severe IVH was more significant in infants of 1000 to 1499 g (AOR: 1.19 vs 1.14; P = .006). The incidence of PVL in VLBW infants was 0.41%, and rates did not differ between genders (0.38% vs 0.43%; P = .42).
Compared with girls, VLBW male newborns are at greater risk to develop IVH and severe IVH but not PVL. The association of male gender with IVH or severe IVH is stronger with higher BWs.
在一个大型国家数据库中，研究性别与脑室内出血（IVH）或脑室周围白质软化（PVL）之间的关系。
分析了 1998 年、1999 年、2001 年、2002 年和 2004 年的全国住院患者样本数据库及其儿科版本，以及 1997 年、2000 年和 2003 年的儿科版本。全国住院患者样本及其儿科版本是每年从美国 1000 多家医院收集的住院患者入院数据。我们纳入了所有极低出生体重（VLBW）婴儿（出生体重 <1500 克），并排除了有重大先天畸形的婴儿。通过使用国际疾病分类，第九版诊断代码，识别患有 IVH 或 PVL 的 VLBW 婴儿。我们使用卡方和 Fisher 确切检验分析数据，计算比值比（OR），并进行逻辑回归分析以控制可能的混杂因素。
数据包括 104847 名 VLBW 婴儿。在控制了显著的混杂因素后，IVH 与男性性别相关（15.9%比 13.6%；调整后的 OR [AOR]：1.15[95%置信区间：1.11-1.19]；P<0.001）。与女孩相比，更多的男孩患有严重的 IVH（38%比 32.7%；AOR：1.18[95%置信区间：1.06-1.32]；P<0.004）。男孩的 IVH 和严重 IVH 发生率在 <1000 克和 1000-1499 克的体重亚组中显著增加。在 1000-1499 克的婴儿中，男性与 IVH 和严重 IVH 的相关性更为显著（AOR：1.19 比 1.14；P=0.006）。VLBW 婴儿的 PVL 发生率为 0.41%，性别之间的发生率无差异（0.38%比 0.43%；P=0.42）。
与女孩相比，VLBW 男婴发生 IVH 和严重 IVH 的风险更高，但发生 PVL 的风险没有差异。男性性别与 IVH 或严重 IVH 的关系在较高的体重时更强。
