Sato Naoyuki, Ozaki Takashi J, Someya Yoshiaki, Anami Kimitaka, Ogawa Seiji, Mizuhara Hiroaki, Yamaguchi Yoko
Department of Complex Systems, School of Systems Information Science, Future University-Hakodate, Hakodate, Hokkaido 041-8655, Japan.
Neuroreport. 2010 Feb 17;21(3):168-72. doi: 10.1097/WNR.0b013e328332072a.
The 4-12 Hz (theta rhythm)-dependent neural dynamics play a fundamental role in the memory formation of the rat hippocampus. Although the power of human scalp electroencephalography theta (EEG theta) is known to be associated with a hippocampus-dependent memory encoding, it remains unclear whether the human hippocampus uses theta rhythm. In this study, we aim to identify the scalp EEG theta-related neural regions during memory encoding by using a simultaneous EEG-functional magnetic resonance imaging recording. We showed that the parahippocampal and the medial frontal and posterior regions were significantly correlated to subsequent memory-dependent EEG theta power. This evidence suggests that the human parahippocampal region and associated structures use theta rhythm during hippocampal memory encoding as in rodents.
4-12赫兹（θ节律）相关的神经动力学在大鼠海马体的记忆形成中起着基础性作用。尽管已知人类头皮脑电图θ波（EEG θ）的功率与海马体依赖的记忆编码有关，但人类海马体是否利用θ节律仍不清楚。在本研究中，我们旨在通过同步脑电图-功能磁共振成像记录来识别记忆编码过程中与头皮EEG θ相关的神经区域。我们发现海马旁回、内侧额叶和后部区域与随后依赖记忆的EEG θ功率显著相关。这一证据表明，人类海马旁回区域及相关结构在海马体记忆编码过程中如同啮齿动物一样利用θ节律。
