Chua Elizabeth F, Schacter Daniel L, Rand-Giovannetti Erin, Sperling Reisa A
Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Hippocampus. 2007;17(11):1071-80. doi: 10.1002/hipo.20340.
It has been well established that the hippocampal formation plays a critical role in the formation of memories. However, functional specialization within the hippocampus remains controversial. Using functional magnetic resonance imaging (fMRI) during a face-name associative encoding task, followed by a postscan recognition test for face memory and face-name pair memory, we investigated the roles of anterior and posterior hippocampal regions in successful encoding of associations and items. Whole-brain and region of interest (ROI) analyses revealed that the anterior hippocampal formation showed increased activation for subsequently remembered face-name associations compared with pairs that were forgotten. In contrast, the posterior hippocampal formation showed activation above baseline during attempted encoding of face-name pairs, but no evidence of differential activation based on subsequent memory. Furthermore, exploratory whole-brain analyses revealed that a parahippocampal region, most likely corresponding to perirhinal cortex, showed subsequent memory effects for faces. These data provide evidence for functional specialization within the hippocampal formation based on the associative nature of the stimuli and subsequent memory.
海马结构在记忆形成中起着关键作用，这一点已得到充分证实。然而，海马体内的功能特化仍存在争议。我们在一项面孔-名字联想编码任务中使用功能磁共振成像（fMRI），随后进行扫描后对面孔记忆和面孔-名字对记忆的识别测试，研究了海马前区和后区在成功编码联想和项目中的作用。全脑和感兴趣区域（ROI）分析显示，与被遗忘的对相比，海马前区对随后记住的面孔-名字联想表现出增强的激活。相比之下，海马后区在尝试编码面孔-名字对时表现出高于基线的激活，但没有基于后续记忆的差异激活证据。此外，探索性全脑分析显示，一个最有可能对应于嗅周皮质的海马旁区域对面孔表现出后续记忆效应。这些数据为基于刺激的联想性质和后续记忆的海马结构内功能特化提供了证据。
