调控组织特异性 T 细胞：CTLA-4 抑制自身反应性 T 细胞。
Taming tissue-specific T cells: CTLA-4 reins in self-reactive T cells.
机构信息
Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Nat Immunol. 2010 Feb;11(2):109-11. doi: 10.1038/ni0210-109.
Abstract
CTLA-4 is a potent co-inhibitory molecule that is critical for peripheral T cell tolerance. A report in this issue reveals the autoantigen-specific nature of CTLA-4-deficient CD4 T cells within target tissue. studies demonstrate that CTLA-4 expression by self-reactive effector cells is sufficient to limit their infiltration into target tissue and that regulatory T cells expressing CTLA-4 can control autoantigen-specific effector T cells. Thus, these findings provide evidence that CTLA-4 exerts its critical immunoregulatory functions by controlling conventional T cells as well as regulatory T cells.
摘要
CTLA-4 是一种有效的共抑制分子，对外周 T 细胞耐受至关重要。本期杂志中的一篇报道揭示了 CTLA-4 缺陷型 CD4 T 细胞在靶组织中的自身抗原特异性。研究表明，自身反应性效应细胞表达 CTLA-4 足以限制其浸润到靶组织，表达 CTLA-4 的调节性 T 细胞可以控制自身抗原特异性效应 T 细胞。因此，这些发现提供了证据表明 CTLA-4 通过控制常规 T 细胞和调节性 T 细胞来发挥其关键的免疫调节功能。
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