记忆问题和大脑萎缩率增加：轻度认知障碍和阿尔茨海默病的危险因素。
Memory complaints and increased rates of brain atrophy: risk factors for mild cognitive impairment and Alzheimer's disease.
机构信息
Dementia Research Centre, UCL Institute of Neurology, London, UK.
出版信息
Int J Geriatr Psychiatry. 2010 Nov;25(11):1119-26. doi: 10.1002/gps.2440.
AIM
To determine rates of cerebral atrophy in individuals with symptoms of memory loss but no objective cognitive impairment (SNCI) and their association with future cognitive decline.
METHODS
Thirty-two SNCI subjects, 16 with mild cognitive impairment (MCI) and 27 control subjects had clinical assessment and magnetic resonance imaging at baseline and 1 year later. Rates of whole brain atrophy (WBA), hippocampal atrophy (HA) and ventricular enlargement (VE) were measured. Our outcome was clinical diagnosis at 2 years after entry into the study.
RESULTS
The MCI group had greater rates of WBA, HA and VE than both controls and SNCI subjects. As a group SNCI subjects did not have significantly greater rates of atrophy than the controls. However, SNCI subjects who progressed to MCI or dementia had increased rates of atrophy compared with those who remained stable.
DISCUSSION
Individuals with memory complaints but no objective memory deficits, who progress to MCI or dementia, have increased rates of cerebral atrophy.
目的
确定有记忆障碍症状但无客观认知障碍（SNCI）的个体的脑萎缩率及其与未来认知能力下降的关系。
方法
32 名 SNCI 受试者，16 名轻度认知障碍（MCI）患者和 27 名对照受试者在基线和 1 年后进行临床评估和磁共振成像。测量全脑萎缩率（WBA）、海马体萎缩率（HA）和脑室扩大率（VE）。我们的预后是研究入组后 2 年的临床诊断。
结果
MCI 组的 WBA、HA 和 VE 比对照组和 SNCI 组的患者都高。作为一个整体，SNCI 组的萎缩率没有比对照组显著增加。然而，从 SNCI 发展为 MCI 或痴呆的患者的脑萎缩率比那些保持稳定的患者增加了。
讨论
有记忆障碍但无客观记忆缺陷、进展为 MCI 或痴呆的个体，脑萎缩率增加。
Zotero 插件