Department of Genetics, Biology and Biochemistry, CERMS, Centre for Experimental Research and Medical Studies, University of Turin, Italy.
Cell Biochem Funct. 2010 Mar;28(2):142-8. doi: 10.1002/cbf.1633.
Different haptoglobin (Hp) phenotypes play a role in several pathologic processes including infectious diseases. In order to evaluate the role of iron storage and metabolism in susceptibility to herpetic manifestations, we studied the frequency of the Hp phenotypes and iron metabolism in patients affected by H. Simplex virus 1 or 2 (HSV-1 or HSV-2), compared with controls. Hp phenotype and iron metabolism were determined in 100 patients with recurrent HSV-1 or HSV-2 manifestations during the relapses, and in 110 healthy subjects. The frequencies of the three Hp phenotypes in the patient group compared to the control group were 18% versus 14.5% p = NS for Hp 1.1, 25% versus 40% p = 0.03 for Hp 2.2 and 57% versus 45.5% p = NS for Hp 2.1. All iron metabolism parameters tested showed significant differences between patients and controls; haemoglobin (Hb), ferritin, and serum iron were lower, while transferrin was higher in the patients than in controls. Reductions in iron availability may be a risk factor for relapsing lesions of HSV-1 or HSV-2. Hp 2.2 phenotype may offer some protection against the recurrence of Herpes labialis or genitalis manifestations.
不同的触珠蛋白（Hp）表型在包括传染病在内的多种病理过程中发挥作用。为了评估铁储存和代谢在单纯疱疹病毒 1 或 2（HSV-1 或 HSV-2）感染表现易感性中的作用，我们研究了 Hp 表型和铁代谢在 HSV-1 或 HSV-2 复发性患者中的频率，与对照组进行了比较。在 100 名复发性 HSV-1 或 HSV-2 表现的患者和 110 名健康受试者中，测定了 Hp 表型和铁代谢。与对照组相比，患者组三种 Hp 表型的频率分别为 18%比 14.5%（Hp 1.1，p=NS），25%比 40%（Hp 2.2，p=0.03）和 57%比 45.5%（Hp 2.1，p=NS）。所有测试的铁代谢参数在患者和对照组之间均有显著差异；患者的血红蛋白（Hb）、铁蛋白和血清铁较低，而转铁蛋白较高。铁供应减少可能是 HSV-1 或 HSV-2 复发性病变的危险因素。Hp 2.2 表型可能对复发性唇疱疹或生殖器疱疹表现提供一定的保护作用。
