子宫肉瘤：科威特癌症控制中心14年经验

Al Wakiel H, Ragheb A M, Varghese A, Juzeer A, Vashista S, Albasmy A

Radiation Oncology Department, Kuwait Cancer Control Centre.

Gulf J Oncolog. 2008 Jul(4):45-51.

AIM OF THE WORK

To asses the profile, pattern of failure and survival for patients with uterine sarcoma seen in KCCC.

MATERIAL AND METHODS

A total of 23 records for patients with uterine sarcoma attending KCCC between July 1993 to May 2007 were available for review. The medical records were assessed for the profile of the disease, histological types, types of treatment, pattern of failure and survival. All cases were proven histologically. The majority of cases 15/23 (65.2%) were endometrial stromal sarcoma, 4/23 (17.4%) had leiomyosarcoma and 4/23 (17.4%) had carcinosarcoma. Twenty two out of 23 patients (95.6%) had surgery and 8/22 (36.4%) were given adjuvant post-operative pelvic radiotherapy. Three patients were treated with palliative intent by radiation. Five patients received palliative chemotherapy.

RESULTS

The mean age of all patients was 53.17+/-11.06 (range 34-80 years). The majority of patients 15/23 (65.2%) had stage I disease. High tumor grade was seen in 12/23 (52.2%) of patients. The pattern of failure was local in only 2 patients, systemic in 4 patients and both local and systemic in 5 patients. The overall DFS-5 years was 59.6%.The 5 y-DFS for patients treated by surgery & RT was 87.5% compared to 36.4% for those treated by surgery alone. Patients with early disease (stage I) had a 5 year DFS of 74% compared to 33.3% for those with advanced disease (stages III&IV). Patients with high grade tumors had a 5 year- DFS of 27% versus 100% for those with low grade tumors.

CONCLUSION

Stage and grade are important predictors of survival. Post-operative adjuvant pelvic irradiation is associated with improved 5-years DFS.

研究目的

评估在肯尼亚癌症中心（KCCC）就诊的子宫肉瘤患者的概况、失败模式及生存率。

材料与方法

共有1993年7月至2007年5月期间在KCCC就诊的23例子宫肉瘤患者的记录可供回顾。对病历进行疾病概况、组织学类型、治疗方式、失败模式及生存率的评估。所有病例均经组织学证实。大多数病例15/23（65.2%）为子宫内膜间质肉瘤，4/23（17.4%）为平滑肌肉瘤，4/23（17.4%）为癌肉瘤。23例患者中有22例（95.6%）接受了手术，8/22（36.4%）接受了术后盆腔辅助放疗。3例患者接受姑息性放疗。5例患者接受姑息性化疗。

结果

所有患者的平均年龄为53.17±11.06岁（范围34 - 80岁）。大多数患者15/23（65.2%）为I期疾病。12/23（52.2%）的患者肿瘤分级高。仅2例患者的失败模式为局部，4例为全身，5例为局部和全身。5年总无病生存率（DFS）为59.6%。接受手术及放疗的患者5年DFS为87.5%，而仅接受手术治疗的患者为36.4%。早期疾病（I期）患者的5年DFS为74%，而晚期疾病（III期和IV期）患者为33.3%。高分级肿瘤患者的5年DFS为27%，而低分级肿瘤患者为100%。