Kshirsagar Ashok Yadavrao, Wader Jyotsna, Shekhar Neeraj, Vinchurkar Kumar Mallesh, Zaware Sagar Uday, Bhosale Hanumant Bhagwan
Department of Surgery and Pathology, Krishna Institute of Medical Sciences, Karad, Maharashtra, India.
Int Surg. 2008 Nov-Dec;93(6):354-7.
Carcinoids are solid tumors of entero-chromaffin origin classified as neuroendocrine amine precursor uptake and decarboxylation (APUD) cell tumors and are found throughout the gastrointestinal tract from the stomach to the rectum, with a predilection for the ileum. These tumors rarely occur in the stomach, constituting only 2% of gastric tumors and 3.3% of all carcinoid tumors of the gastrointestinal tract. Localization of gastric tumors can be done by ultrasonography, computed tomography, and magnetic resonance imaging, but endoscopic biopsy is required for confirmation; demonstration of neurosecretory granules on microscopy is the most specific feature. Early resection is the treatment of choice. Prognosis of noninvasive tumors <2 cm in size in terms of 5-year survival rate is 100%. The 5-year survival rate declines and prognosis becomes poor with increase in size and with involvement of serosa, perineural infiltration, and lymph node metastasis.
类癌是起源于肠嗜铬细胞的实体瘤,归类为神经内分泌胺前体摄取与脱羧(APUD)细胞瘤,可见于从胃到直肠的整个胃肠道,以回肠最为多见。这些肿瘤很少发生在胃,仅占胃肿瘤的2%以及胃肠道所有类癌肿瘤的3.3%。胃肿瘤的定位可通过超声检查、计算机断层扫描和磁共振成像来完成,但确诊需要内镜活检;显微镜下神经分泌颗粒的显示是最具特异性的特征。早期切除是首选的治疗方法。大小<2 cm的非侵袭性肿瘤的5年生存率为100%。随着肿瘤大小增加以及浆膜受累、神经周围浸润和淋巴结转移,5年生存率下降且预后变差。