Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece.
Biomarkers. 2010 Feb;15(1):69-79. doi: 10.3109/13547500903297184.
A synopsis and meta-analysis of studies that investigated the association between genetic variants involved in the homocysteine/folate metabolism pathway and risk of inflammatory bowel disease (IBD) were conducted. Four variants (MTHFR C6TTT, MTHFR A1298C, MTR A2756G and MTRR A66G) showed significant associations in individual studies. In meta-analyses, only the variant MTR A2756G indicated an association with the risk of IBD for the allele contrast and the dominant model (odds ratio (OR) 1.48 (1.12-1.97) and OR 1.55 (1.12-2.15), respectively). The effect sizes for Crohn's disease and ulcerative colitis were similar to IBD. Cumulative meta-analysis for C677T indicated a downward trend of association as information accumulates.
对研究同型半胱氨酸/叶酸代谢途径中涉及的遗传变异与炎症性肠病（IBD）风险之间关联的研究进行了总结和荟萃分析。四项变异（MTHFR C6TTT、MTHFR A1298C、MTR A2756G 和 MTRR A66G）在单项研究中显示出显著相关性。在荟萃分析中，只有 MTR A2756G 变异在等位基因对比和显性模型中与 IBD 风险相关（比值比（OR）1.48（1.12-1.97）和 OR 1.55（1.12-2.15））。克罗恩病和溃疡性结肠炎的效应大小与 IBD 相似。随着信息的积累，C677T 的累积荟萃分析表明关联呈下降趋势。
