赛曲哚尔对 QT 离散度和 QT 离散度的影响。

The effect of sertindole on QTD and TPTE.

机构信息

Aalborg Psychiatric Hospital, Aarhus University Hospital, Denmark.

出版信息

Acta Psychiatr Scand. 2010 May;121(5):385-8. doi: 10.1111/j.1600-0447.2009.01534.x. Epub 2010 Jan 19.

DOI:10.1111/j.1600-0447.2009.01534.x

PMID:20085555

Abstract

OBJECTIVE

Recent research suggests that other surrogate markers than QTc, including QTc dispersion and Tpeak-Tend, may better correlate with cardiac arrhythmia risk. While sertindole significantly prolongs the QTc interval, the effects on other markers of arrhythmia risk, such as QTc dispersion and Tpeak-Tend are unknown.

METHOD

Digital 12-lead ECG was recorded at baseline and at steady-state in 37 patients switched to sertindole. ECG was analysed for Fridericia-corrected QT duration (QTcF), QT dispersion and Tpeak-Tend.

RESULTS

From a baseline QTcF of 407 +/- 22 ms, mean QTcF prolongation during sertindole treatment was 20 +/- 23 ms, P < 0.01. No effect on QTc dispersion was found (-1 +/- 11 ms; P = 0.41). No increased duration of the Tpeak-Tend interval from baseline was found (+7 +/- 21 ms; P = 0.05).

CONCLUSION

These findings might be related to the absence of confirmed Torsade de Pointes (TdP) cases related to sertindole exposure, despite sertindole's QTc prolonging effects.

摘要

目的

最近的研究表明，除 QTc 以外的其他替代标志物，包括 QTc 离散度和 Tpeak-Tend，可能与心律失常风险更好地相关。虽然舍吲哚显著延长 QTc 间期，但对心律失常风险的其他标志物（如 QTc 离散度和 Tpeak-Tend）的影响尚不清楚。

方法

37 例转换为舍吲哚的患者在基线和稳态时记录数字 12 导联心电图。对 Fridericia 校正 QT 持续时间（QTcF）、QT 离散度和 Tpeak-Tend 进行心电图分析。

结果

舍吲哚治疗期间，从基线 QTcF 的 407 +/- 22 ms 开始，平均 QTcF 延长 20 +/- 23 ms，P < 0.01。未发现 QTc 离散度的影响（-1 +/- 11 ms；P = 0.41）。与基线相比，Tpeak-Tend 间隔的持续时间没有增加（+7 +/- 21 ms；P = 0.05）。