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1
Ductal origin hypothesis of pancreatic regeneration under attack.胰腺再生的导管起源假说受到抨击。
Cell Metab. 2010 Jan;11(1):2-3. doi: 10.1016/j.cmet.2009.12.005.
2
Intraislet Pancreatic Ducts Can Give Rise to Insulin-Positive Cells.胰岛内的胰管可产生胰岛素阳性细胞。
Endocrinology. 2016 Jan;157(1):166-75. doi: 10.1210/en.2015-1175. Epub 2015 Oct 27.
3
Functional association of the morphogenic factors with the clusterin for the pancreatic beta-cell differentiation.形态发生因子与簇集蛋白在胰腺β细胞分化中的功能关联。
Diabetes Res Clin Pract. 2007 Sep;77 Suppl 1:S122-6. doi: 10.1016/j.diabres.2007.01.045. Epub 2007 May 23.
4
Islet formation and regeneration.胰岛的形成与再生。
Chin Med Sci J. 2006 Mar;21(1):27-32.
5
Differentiation of affinity-purified human pancreatic duct cells to beta-cells.亲和纯化的人胰腺导管细胞向β细胞的分化。
Diabetes. 2007 Jul;56(7):1802-9. doi: 10.2337/db06-1670. Epub 2007 May 1.
6
Ductal Cell Reprogramming to Insulin-Producing Beta-Like Cells as a Potential Beta Cell Replacement Source for Chronic Pancreatitis.导管细胞重编程为产生胰岛素的β样细胞作为慢性胰腺炎潜在的β细胞替代来源
Curr Stem Cell Res Ther. 2019;14(1):65-74. doi: 10.2174/1574888X13666180918092729.
7
Transdifferentiation of pancreatic ductal cells to endocrine beta-cells.胰腺导管细胞向内分泌β细胞的转分化。
Biochem Soc Trans. 2008 Jun;36(Pt 3):353-6. doi: 10.1042/BST0360353.
8
Origin of beta-cells in regenerating pancreas.再生胰腺中β细胞的起源。
Bioessays. 2008 Jul;30(7):617-20. doi: 10.1002/bies.20779.
9
Regulation of pancreas plasticity and malignant transformation by Akt signaling.Akt信号通路对胰腺可塑性和恶性转化的调控
Gastroenterology. 2009 Mar;136(3):1091-103. doi: 10.1053/j.gastro.2008.11.043. Epub 2008 Nov 27.
10
β-Cell regeneration through the transdifferentiation of pancreatic cells: Pancreatic progenitor cells in the pancreas.β 细胞通过胰腺细胞的转分化再生:胰腺中的胰腺祖细胞。
J Diabetes Investig. 2016 May;7(3):286-96. doi: 10.1111/jdi.12475. Epub 2016 Feb 29.

引用本文的文献

1
β-Cell Regeneration Is Driven by Pancreatic Plasticity.β 细胞再生由胰腺可塑性驱动。
Adv Anat Embryol Cell Biol. 2024;239:91-115. doi: 10.1007/978-3-031-62232-8_4.
2
Insulin-positive ductal cells do not migrate into preexisting islets during pregnancy.胰岛素阳性的导管细胞在妊娠期间不会迁移到已存在的胰岛中。
Exp Mol Med. 2021 Apr;53(4):605-614. doi: 10.1038/s12276-021-00593-z. Epub 2021 Apr 5.
3
PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice.PAHSAs 可减弱自身免疫性糖尿病小鼠的免疫反应并促进β细胞存活。
J Clin Invest. 2019 Aug 5;129(9):3717-3731. doi: 10.1172/JCI122445.
4
Emerging Roles for Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) in Pancreatic Beta Cells and Diabetes.中脑星形胶质细胞衍生神经营养因子(MANF)在胰腺β细胞和糖尿病中的新作用
Front Physiol. 2018 Oct 16;9:1457. doi: 10.3389/fphys.2018.01457. eCollection 2018.
5
In the setting of β-cell stress, the pancreatic duct gland transcriptome shows characteristics of an activated regenerative response.在β细胞应激的情况下,胰腺导管腺转录组显示出激活的再生反应的特征。
Am J Physiol Gastrointest Liver Physiol. 2018 Nov 1;315(5):G848-G854. doi: 10.1152/ajpgi.00177.2018. Epub 2018 Aug 10.
6
Heterogeneity of SOX9 and HNF1β in Pancreatic Ducts Is Dynamic.SOX9 和 HNF1β 在胰腺导管中的异质性是动态的。
Stem Cell Reports. 2018 Mar 13;10(3):725-738. doi: 10.1016/j.stemcr.2018.01.028. Epub 2018 Mar 1.
7
Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes.病毒基因治疗诱导的α细胞内源性重编程为β细胞可逆转自身免疫性糖尿病。
Cell Stem Cell. 2018 Jan 4;22(1):78-90.e4. doi: 10.1016/j.stem.2017.11.020.
8
Increased Proliferation of the Pancreatic Duct Gland Compartment in Type 1 Diabetes.1型糖尿病中胰腺导管腺区增殖增加。
J Clin Endocrinol Metab. 2017 Jan 1;102(1):200-209. doi: 10.1210/jc.2016-3001.
9
Stem cells to replace or regenerate the diabetic pancreas: Huge potential & existing hurdles.用于替代或再生糖尿病胰腺的干细胞:巨大潜力与现存障碍。
Indian J Med Res. 2016 Mar;143(3):267-74. doi: 10.4103/0971-5916.182615.
10
Centroacinar cells: At the center of pancreas regeneration.腺泡中心细胞:胰腺再生的核心。
Dev Biol. 2016 May 1;413(1):8-15. doi: 10.1016/j.ydbio.2016.02.027. Epub 2016 Mar 8.

本文引用的文献

1
Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth.在胚胎发生过程中,胰腺外分泌导管细胞会产生胰岛素分泌的β细胞,但出生后不会。
Dev Cell. 2009 Dec;17(6):849-60. doi: 10.1016/j.devcel.2009.11.003.
2
Cellular origins of beta-cell regeneration: a legacy view of historical controversies.β细胞再生的细胞起源:历史争议的传统观点
J Intern Med. 2009 Oct;266(4):325-38. doi: 10.1111/j.1365-2796.2009.02156.x.
3
A role for islet neogenesis in curing diabetes.胰岛新生在治愈糖尿病中的作用。
Diabetologia. 2009 May;52(5):735-8. doi: 10.1007/s00125-009-1322-y. Epub 2009 Mar 7.
4
Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth.碳酸酐酶II阳性的胰腺细胞是出生后内分泌和外分泌胰腺的祖细胞。
Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19915-9. doi: 10.1073/pnas.0805803105. Epub 2008 Dec 3.
5
Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas.β细胞可由成年小鼠受损胰腺中的内源性祖细胞生成。
Cell. 2008 Jan 25;132(2):197-207. doi: 10.1016/j.cell.2007.12.015.
6
Recovery from diabetes in mice by beta cell regeneration.通过β细胞再生实现小鼠糖尿病的恢复。
J Clin Invest. 2007 Sep;117(9):2553-61. doi: 10.1172/JCI32959.
7
All beta cells contribute equally to islet growth and maintenance.所有β细胞对胰岛的生长和维持都有同等贡献。
PLoS Biol. 2007 Jul;5(7):e163. doi: 10.1371/journal.pbio.0050163. Epub 2007 May 29.
8
Growth and regeneration of adult beta cells does not involve specialized progenitors.成年β细胞的生长和再生不涉及特定的祖细胞。
Dev Cell. 2007 May;12(5):817-26. doi: 10.1016/j.devcel.2007.04.011.
9
Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation.成年胰腺β细胞是通过自我复制而非干细胞分化形成的。
Nature. 2004 May 6;429(6987):41-6. doi: 10.1038/nature02520.
10
Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57Bl6/J mice treated with alloxan.联合胃泌素和表皮生长因子治疗可诱导用四氧嘧啶处理的C57Bl6/J小鼠的胰岛再生并恢复正常血糖水平。
Diabetologia. 2004 Feb;47(2):259-65. doi: 10.1007/s00125-003-1287-1. Epub 2003 Dec 10.

Ductal origin hypothesis of pancreatic regeneration under attack.

作者信息

Kushner Jake A, Weir Gordon C, Bonner-Weir Susan

出版信息

Cell Metab. 2010 Jan;11(1):2-3. doi: 10.1016/j.cmet.2009.12.005.

DOI:10.1016/j.cmet.2009.12.005
PMID:20085728
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3762572/
Abstract
摘要