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Ductal origin hypothesis of pancreatic regeneration under attack.

作者信息

Kushner Jake A, Weir Gordon C, Bonner-Weir Susan

出版信息

Cell Metab. 2010 Jan;11(1):2-3. doi: 10.1016/j.cmet.2009.12.005.

Abstract
摘要

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Cellular origins of beta-cell regeneration: a legacy view of historical controversies.
J Intern Med. 2009 Oct;266(4):325-38. doi: 10.1111/j.1365-2796.2009.02156.x.
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A role for islet neogenesis in curing diabetes.
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Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth.
Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19915-9. doi: 10.1073/pnas.0805803105. Epub 2008 Dec 3.
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Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas.
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Recovery from diabetes in mice by beta cell regeneration.
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All beta cells contribute equally to islet growth and maintenance.
PLoS Biol. 2007 Jul;5(7):e163. doi: 10.1371/journal.pbio.0050163. Epub 2007 May 29.
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