Ecole Polytechnique Fédérale de Lausanne, Switzerland.
Cell Metab. 2010 Jan;11(1):6-7. doi: 10.1016/j.cmet.2009.12.003.
The link between Akt activation and gluconeogenic repression remains unclear, despite many years of investigation and remarkable progress. Rodgers and colleagues now introduce us to the Clk2 kinase, an Akt substrate that can directly phosphorylate and inhibit PGC-1alpha, blunting hepatic glucose production.
尽管经过多年的研究和显著的进展, Akt 激活与糖异生抑制之间的联系仍然不清楚。Rodgers 及其同事现在向我们介绍了 Clk2 激酶,它是 Akt 的底物,可以直接磷酸化并抑制 PGC-1α,从而阻断肝脏葡萄糖的产生。