点击 PGC-1alpha 抑制糖异生。
Clking on PGC-1alpha to inhibit gluconeogenesis.
机构信息
Ecole Polytechnique Fédérale de Lausanne, Switzerland.
出版信息
Cell Metab. 2010 Jan;11(1):6-7. doi: 10.1016/j.cmet.2009.12.003.
Abstract
The link between Akt activation and gluconeogenic repression remains unclear, despite many years of investigation and remarkable progress. Rodgers and colleagues now introduce us to the Clk2 kinase, an Akt substrate that can directly phosphorylate and inhibit PGC-1alpha, blunting hepatic glucose production.
摘要
尽管经过多年的研究和显著的进展， Akt 激活与糖异生抑制之间的联系仍然不清楚。Rodgers 及其同事现在向我们介绍了 Clk2 激酶，它是 Akt 的底物，可以直接磷酸化并抑制 PGC-1α，从而阻断肝脏葡萄糖的产生。
相似文献
1
Clking on PGC-1alpha to inhibit gluconeogenesis.点击 PGC-1alpha 抑制糖异生。
Cell Metab. 2010 Jan;11(1):6-7. doi: 10.1016/j.cmet.2009.12.003.
2
Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis.CDC2 样激酶 2 是一种受胰岛素调控的肝脏糖异生抑制剂。
Cell Metab. 2010 Jan;11(1):23-34. doi: 10.1016/j.cmet.2009.11.006.
3
The metabolic regulator PGC-1α links hepatitis C virus infection to hepatic insulin resistance.代谢调节剂 PGC-1α 将丙型肝炎病毒感染与肝胰岛素抵抗联系起来。
J Hepatol. 2012 Oct;57(4):867-73. doi: 10.1016/j.jhep.2012.06.021. Epub 2012 Jun 23.
4
CITED2 links hormonal signaling to PGC-1α acetylation in the regulation of gluconeogenesis.CITED2 通过调控糖异生将激素信号与 PGC-1α 乙酰化联系起来。
Nat Med. 2012 Mar 18;18(4):612-7. doi: 10.1038/nm.2691.
5
The SMILE transcriptional corepressor inhibits cAMP response element-binding protein (CREB)-mediated transactivation of gluconeogenic genes.SMILE 转录共抑制因子抑制 cAMP 反应元件结合蛋白 (CREB) 介导的糖异生基因的转录激活。
J Biol Chem. 2018 Aug 24;293(34):13125-13133. doi: 10.1074/jbc.RA118.002196. Epub 2018 Jun 27.
6
Endurance exercise training increases APPL1 expression and improves insulin signaling in the hepatic tissue of diet-induced obese mice, independently of weight loss.耐力运动训练可增加 APPL1 的表达，并改善饮食诱导肥胖小鼠肝组织中的胰岛素信号，而与体重减轻无关。
J Cell Physiol. 2012 Jul;227(7):2917-26. doi: 10.1002/jcp.23037.
7
GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha.GCN5 乙酰转移酶复合物通过对 PGC-1α 的转录抑制来控制葡萄糖代谢。
Cell Metab. 2006 Jun;3(6):429-38. doi: 10.1016/j.cmet.2006.04.013.
8
Cdc2-like kinase 2 suppresses hepatic fatty acid oxidation and ketogenesis through disruption of the PGC-1α and MED1 complex.细胞周期蛋白依赖性激酶2样激酶2通过破坏PGC-1α和MED1复合物来抑制肝脏脂肪酸氧化和生酮作用。
Diabetes. 2014 May;63(5):1519-32. doi: 10.2337/db13-1304. Epub 2014 Jan 23.
9
BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humans.肥胖和2型糖尿病患者肝脏中，通过胰岛素受体底物-1（IRS-1）、蛋白激酶B（Akt）、叉头框蛋白O1（FoxO1）和过氧化物酶体增殖物激活受体γ辅激活因子1α（PGC-1α），与体重指数（BMI）相关的非典型蛋白激酶C（PKC）依赖性胰岛素信号转导异常的进展。
Metabolism. 2015 Nov;64(11):1454-65. doi: 10.1016/j.metabol.2015.08.011. Epub 2015 Aug 24.
10
Coordinated regulation of hepatic FoxO1, PGC-1α and SREBP-1c facilitates insulin action and resistance.协调调控肝 FoxO1、PGC-1α 和 SREBP-1c 有助于胰岛素作用和抵抗。
Cell Signal. 2018 Mar;43:62-70. doi: 10.1016/j.cellsig.2017.12.005. Epub 2017 Dec 18.
引用本文的文献
1
Pharmacological inhibition of G protein-coupled receptor kinase 5 decreases high-fat diet-induced hepatic steatosis in mice.G蛋白偶联受体激酶5的药理学抑制作用可减轻高脂饮食诱导的小鼠肝脏脂肪变性。
bioRxiv. 2025 Jun 28:2025.06.25.661655. doi: 10.1101/2025.06.25.661655.
2
Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism.磷酸烯醇丙酮酸羧激酶 1 的类泛素化修饰控制糖代谢。
Cell Metab. 2023 Sep 5;35(9):1630-1645.e5. doi: 10.1016/j.cmet.2023.07.003. Epub 2023 Aug 3.
3
Arginine Methylation of the PGC-1α C-Terminus Is Temperature-Dependent.PGC-1α C 端精氨酸甲基化是温度依赖性的。
Biochemistry. 2023 Jan 3;62(1):22-34. doi: 10.1021/acs.biochem.2c00363. Epub 2022 Dec 19.
4
Comparative Analysis of MicroRNA and mRNA Profiles of Sperm with Different Freeze Tolerance Capacities in Boar () and Giant Panda ().猪和大熊猫精子不同冷冻耐受能力的 microRNA 和 mRNA 谱的比较分析。
Biomolecules. 2019 Sep 1;9(9):432. doi: 10.3390/biom9090432.
5
The KLF14 transcription factor regulates hepatic gluconeogenesis in mice.KLF14 转录因子调节小鼠肝脏的糖异生。
J Biol Chem. 2017 Dec 29;292(52):21631-21642. doi: 10.1074/jbc.RA117.000184. Epub 2017 Nov 9.
6
NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease.烟酰胺腺嘌呤二核苷酸（NAD(+)）依赖性激活沉默调节蛋白1（Sirt1）可纠正线粒体疾病小鼠模型中的表型。
Cell Metab. 2014 Jun 3;19(6):1042-9. doi: 10.1016/j.cmet.2014.04.001. Epub 2014 May 8.
7
Development of a stable cell line with an intact PGC-1α/ERRα axis for screening environmental chemicals.建立具有完整 PGC-1α/ERRα 轴的稳定细胞系，用于筛选环境化学物质。
Biochem Biophys Res Commun. 2014 Feb 7;444(2):177-81. doi: 10.1016/j.bbrc.2014.01.033. Epub 2014 Jan 20.
本文引用的文献
1
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity.AMPK通过调节NAD+代谢和SIRT1活性来调控能量消耗。
Nature. 2009 Apr 23;458(7241):1056-60. doi: 10.1038/nature07813.
2
Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways.通过PGC-1α和SIRT1途径的代谢适应。
FEBS Lett. 2008 Jan 9;582(1):46-53. doi: 10.1016/j.febslet.2007.11.034. Epub 2007 Nov 26.
3
Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator.Akt/PKB通过直接抑制PGC-1α转录共激活因子来调节肝脏代谢。
Nature. 2007 Jun 21;447(7147):1012-6. doi: 10.1038/nature05861. Epub 2007 Jun 6.
4
GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha.GCN5 乙酰转移酶复合物通过对 PGC-1α 的转录抑制来控制葡萄糖代谢。
Cell Metab. 2006 Jun;3(6):429-38. doi: 10.1016/j.cmet.2006.04.013.
5
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.通过PGC-1α和SIRT1复合物对葡萄糖稳态进行营养控制。
Nature. 2005 Mar 3;434(7029):113-8. doi: 10.1038/nature03354.
6
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction.胰岛素通过FOXO1与PGC-1α的相互作用调节肝脏糖异生。
Nature. 2003 May 29;423(6939):550-5. doi: 10.1038/nature01667. Epub 2003 May 18.
7
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.一种与适应性产热相关的核受体冷诱导共激活因子。
Cell. 1998 Mar 20;92(6):829-39. doi: 10.1016/s0092-8674(00)81410-5.
Zotero 插件