Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya 466-8550, Japan.
Microvasc Res. 2010 May;79(3):174-7. doi: 10.1016/j.mvr.2010.01.008. Epub 2010 Jan 18.
The presence of circulating endothelial repopulating cells in the adult human peripheral blood has been proposed since long time ago. In the late 1990s, the putative endothelial progenitor cells (EPCs) were first identified and reported by Asahara and co-workers. Since then, a number of studies have demonstrated that these cells are derived from bone marrow and induce microvascular vasculogenesis and re-endothelialization of injured vessels. Meantime, human umbilical cord blood also gained much attention for the reason of possible additional source to obtain EPCs since cord blood has been shown to contain more number of active hematopoietic stem cells as compared to adult peripheral blood. This review summarizes the aspect of human cord blood-derived EPCs with special focuses into their identity and future clinical application.
很久以前就有人提出，成年人外周血中存在循环内皮再殖细胞。1990 年代末，Asahara 及其同事首次鉴定并报道了所谓的内皮祖细胞（EPCs）。此后，许多研究表明这些细胞源自骨髓，并诱导受损血管的微血管血管生成和再内皮化。与此同时，由于脐血中含有比成人外周血更多数量的活跃造血干细胞，因此脐血也成为获得 EPC 的可能的额外来源，从而引起了人们的广泛关注。本综述总结了人脐血衍生的 EPC 的各个方面，特别关注其特性及其未来的临床应用。
