脐带血来源的内皮祖细胞移植：一种有前景的治疗性血管再生方法。
Transplantation of umbilical cord blood-derived endothelial progenitor cells: a promising method of therapeutic revascularisation.
作者信息
Zhang Lei, Yang Renchi, Han Zhong Chao
机构信息
State Key Laboratory of Experimental Hematology, National Research Center of Stem Cell Engineering and Technology, Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
出版信息
Eur J Haematol. 2006 Jan;76(1):1-8. doi: 10.1111/j.1600-0609.2005.00579.x.
Therapeutic neovascularisation by endothelial progenitor cells (EPCs) mediated vascular regeneration is becoming a novel option for the treatment of ischaemic diseases. Recently, human umbilical cord blood (CB) has been found to contain a large number of EPCs and transplantation of CB EPCs led to a successful salvage of the ischaemic limbs through improvement in blood perfusion, indicating the feasibility of using CB cells for therapeutic revascularisation. This review will summarise recent studies in therapeutic revascularisation using CB cells and discuss the potential clinical utilisation of CB cells in ischaemic diseases.
通过内皮祖细胞（EPCs）介导的血管再生进行治疗性血管新生，正成为治疗缺血性疾病的一种新选择。最近，已发现人脐带血（CB）含有大量EPCs，并且移植CB EPCs通过改善血液灌注成功挽救了缺血肢体，这表明使用CB细胞进行治疗性血管重建的可行性。本综述将总结近期使用CB细胞进行治疗性血管重建的研究，并讨论CB细胞在缺血性疾病中的潜在临床应用。
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