Department of Surgery, Kameda Medical Center, Kamogawa City, Chiba, 296-8602, Japan.
Jpn J Clin Oncol. 2010 May;40(5):412-9. doi: 10.1093/jjco/hyp185. Epub 2010 Jan 18.
Adjuvant chemotherapy with oral uracil/tegafur plus leucovorin has been acknowledged to be a standard treatment for Stage II or III cancer of the colon. The objective of the study was to examine the health-related quality of life during treatment in patients with colorectal cancer who receive oral uracil/tegafur plus leucovorin.
Health-related quality of life was assessed at baseline (pre-treatment) and at 5-week intervals during treatment, using the European Organization for Research and Treatment of Cancer QLQ-C30 questionnaires. Health-related quality of life data for five courses of treatment were then analyzed longitudinally.
Ninety-four patients completed the baseline and post-treatment health-related quality of life assessments. The post-treatment assessments changed significantly from the baseline values and favored post-treatment for all the scales except cognitive function, dyspnea, insomnia, constipation and diarrhea. Role function and social function changed by 10 or more points considered clinically significant. Most of the scales in patients with Grade 0-1 toxicities were better than those with Grade 2-3 toxicities, but Grade 2-3 toxicities were not associated with post-treatment deteriorations in health-related quality of life. The development of Grade 3 toxicities negatively affected on the four scales at the next assessment, compared with Grade 1-2 toxicities.
Overall health-related quality of life did not deteriorate during adjuvant chemotherapy with oral uracil/tegafur plus leucovorin in patients with colorectal cancer, despite the effect from surgical damage, whereas the development of Grade 3 toxicities negatively affected on short-term health-related quality of life. Further comparative studies are needed.
口服替加氟/尿嘧啶加亚叶酸辅助化疗已被公认为结肠癌 II 期或 III 期的标准治疗方法。本研究的目的是检查接受口服替加氟/尿嘧啶加亚叶酸治疗的结直肠癌患者在治疗期间的健康相关生活质量。
使用欧洲癌症研究与治疗组织 EORTC QLQ-C30 问卷，在基线（治疗前）和治疗期间每 5 周评估一次健康相关生活质量。然后对 5 个疗程的健康相关生活质量数据进行纵向分析。
94 例患者完成了基线和治疗后健康相关生活质量评估。除认知功能、呼吸困难、失眠、便秘和腹泻外，治疗后的评估与基线值相比发生了显著变化，并且对所有量表均有利。角色功能和社会功能的变化超过 10 个点被认为具有临床意义。0-1 级毒性患者的大多数量表均优于 2-3 级毒性患者，但 2-3 级毒性与治疗后健康相关生活质量的恶化无关。与 1-2 级毒性相比，3 级毒性的发展在下一次评估中对四个量表产生负面影响。
尽管手术损伤有影响，但在接受结直肠癌口服替加氟/尿嘧啶加亚叶酸辅助化疗期间，患者的总体健康相关生活质量并未恶化，而 3 级毒性的发展对短期健康相关生活质量产生负面影响。需要进一步进行比较研究。
