Department of Epidemiology and Public Health, University College London, London, UK.
Diabetes Care. 2010 Apr;33(4):792-7. doi: 10.2337/dc09-1663. Epub 2010 Jan 19.
To examine the association between baseline elevated depressive symptoms and incident type 2 diabetes in a national sample of people aged > or =50 years.
The sample consisted of 6,111 individuals free from self-reported doctor-diagnosed diabetes at baseline in 2002-2003. The eight-item Center for Epidemiological Studies-Depression (CES-D) scale was the measurement of depressive symptoms. Cox proportional hazards regression models were used to assess whether baseline elevated (> or =4) depressive symptoms were associated with a higher risk of type 2 diabetes over 45.8 months of follow-up.
The hazard ratio (HR) for diabetes was 1.62 (95% CI 1.15-2.29) in a model adjusted for age, sex, marital status, education, total net household wealth, cardiovascular and psychiatric and other noncardiovascular comorbidities, BMI, and health behaviors for participants with elevated CES-D symptoms compared with those without. Complementary analysis performed for a subsample (n = 5,090) showed that additional adjustment of this model for use of antidepressants did not explain the association (HR 1.58, 95% CI 1.09-2.29).
Elevated depressive symptoms were associated with a higher risk of developing type 2 diabetes after accounting for sociodemographic, lifestyle, and clinical factors in a national sample of people aged > or =50 years.
在一个年龄大于等于 50 岁的全国性样本中，研究基线时抑郁症状升高与 2 型糖尿病发病的相关性。
该样本包括 6111 名在 2002-2003 年基线时无自我报告的医生诊断为糖尿病的个体。使用 8 项的流行病学研究中心抑郁量表（CES-D）来衡量抑郁症状。使用 Cox 比例风险回归模型来评估基线时升高的（>=4）抑郁症状是否与 45.8 个月的随访期间更高的 2 型糖尿病风险相关。
在调整年龄、性别、婚姻状况、教育程度、总净家庭财富、心血管和精神及其他非心血管合并症、BMI 和健康行为的模型中，CES-D 症状升高的参与者的糖尿病发病风险比（HR）为 1.62（95%CI 1.15-2.29）。对亚样本（n=5090）进行的补充分析表明，该模型中进一步调整使用抗抑郁药并不能解释这种关联（HR 1.58，95%CI 1.09-2.29）。
在考虑了年龄大于等于 50 岁的全国性样本中的社会人口统计学、生活方式和临床因素后，升高的抑郁症状与 2 型糖尿病发病风险增加相关。
