Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Mol Syst Biol. 2010;6:343. doi: 10.1038/msb.2009.98. Epub 2010 Jan 19.
The molecular understanding of phenotypes caused by drugs in humans is essential for elucidating mechanisms of action and for developing personalized medicines. Side effects of drugs (also known as adverse drug reactions) are an important source of human phenotypic information, but so far research on this topic has been hampered by insufficient accessibility of data. Consequently, we have developed a public, computer-readable side effect resource (SIDER) that connects 888 drugs to 1450 side effect terms. It contains information on frequency in patients for one-third of the drug-side effect pairs. For 199 drugs, the side effect frequency of placebo administration could also be extracted. We illustrate the potential of SIDER with a number of analyses. The resource is freely available for academic research at http://sideeffects.embl.de.
人类药物引起的表型的分子认识对于阐明作用机制和开发个体化药物至关重要。药物的副作用（也称为药物不良反应）是人类表型信息的重要来源，但迄今为止，由于数据获取不足，该主题的研究受到阻碍。因此，我们开发了一个公共的、计算机可读的副作用资源（SIDER），将 888 种药物与 1450 种副作用术语联系起来。它包含三分之一的药物-副作用对的患者频率信息。对于 199 种药物，也可以提取安慰剂给药的副作用频率。我们通过一些分析来说明 SIDER 的潜力。该资源可在 http://sideeffects.embl.de 上免费供学术研究使用。
