Department of General Surgery, Singapore General Hospital, Outram Road, Singapore.
Singapore Med J. 2009 Dec;50(12):1139-44.
Intestinal obstruction commonly occurs in advanced abdominal and pelvic malignancy. Management of these patients is difficult, as it is uncertain which patients benefit from palliative surgery and which benefit from medical management.
Clinical records for patients who underwent surgery for palliation of bowel obstruction were reviewed retrospectively. All had metastatic malignant disease and were seen by the general surgical department for intestinal obstruction. The following factors were examined: preoperative albumin, APACHE II score, age, site of metastases, presence of ascites, operative findings and type of operative procedure performed, length of postoperative stay and mortality.
27 palliative operations for intestinal obstruction for metastatic malignancy were performed during this period. This included two patients who were re-operated on for recurrence of intestinal obstruction after recovering from the first operation. All patients had radiological evidence of intestinal obstruction preoperatively. All patients who survived were discharged from hospital without requiring parenteral nutrition or hydration, and were able to tolerate oral medication and feeds. In this small series, site of metastases, presence of ascites, APACHE II score and gender were not predictive of mortality. An albumin level of 21 g/L or less was predictive of mortality. Almost 50 percent of these patients would require a stoma. Our series had a 30-day mortality rate of 20 percent.
Surgery does have a role in palliation of symptoms of intestinal obstruction in carefully selected patients with advanced abdominal and pelvic malignancy. Patients should be counselled on the likelihood of a stoma and the 30-day mortality risk.
肠梗阻在晚期腹部和盆腔恶性肿瘤中很常见。这些患者的治疗较为困难,因为不确定哪些患者从姑息性手术中获益,哪些患者从药物治疗中获益。
回顾性分析接受姑息性手术治疗肠梗阻的患者的临床记录。所有患者均患有转移性恶性肿瘤,且因肠梗阻就诊于普通外科。检查了以下因素:术前白蛋白、APACHE II 评分、年龄、转移部位、腹水存在情况、手术发现和手术类型、术后住院时间和死亡率。
在此期间,对转移性恶性肿瘤的 27 例肠梗阻进行了姑息性手术。其中包括两名患者在第一次手术后从肠梗阻中恢复后再次接受手术治疗以治疗肠梗阻复发。所有患者术前均有影像学肠梗阻证据。所有存活患者均未接受肠外营养或补液而出院,能够耐受口服药物和饮食。在本小系列中,转移部位、腹水存在情况、APACHE II 评分和性别均不能预测死亡率。白蛋白水平为 21 g/L 或更低与死亡率相关。这些患者中几乎有 50%需要造口。我们的系列研究中有 30 天的死亡率为 20%。
在精心选择的晚期腹部和盆腔恶性肿瘤患者中,手术确实可以缓解肠梗阻的症状。应告知患者造口的可能性和 30 天死亡率风险。