Laboratory of Hygiene and Environmental Virology, Faculty of Medicine, Department of Public Health, University of Tor Vergata, Rome, Italy.
J Med Virol. 2010 Mar;82(3):510-8. doi: 10.1002/jmv.21700.
Rotaviruses are one of the most important causes of gastroenteritis in children under 5 years old. Analysis of G and P rotavirus genotypes in circulation is crucial in evaluating the appropriacy of mass vaccination of children worldwide. Overall, 592 stool samples were collected in Tirana (Albania), the Salento peninsula (South Italy), and three different hospitals in Rome (Central Italy). Of the total samples, 31.3% were rotavirus positive in Albania, 78.3% in the Salento, and 40.3% in Rome. The samples collected in Tirana and Rome were G-P typed, whereas the samples collected in the Salento were only G typed. Overall, in Italy the most frequent combinations were G4 P[8] (54.5%), G1 P[8] (27.3%), and G2 P[4] (18.2%); in Albania they were G9 P[8] (72.1%), G4 P[8] (8.8%), G1 P[8] (5.9%), and G2 P[4] (2.9%). The prevalence in Albania of atypical combinations was 7.4% for G4 P[4] and 2.9% for G9 P[4]. Phylogenetic analysis was also performed to assess the genetic relatedness of the strains. J. Med. Virol. 82:510-518, 2010. (c) 2010 Wiley-Liss, Inc.
轮状病毒是导致 5 岁以下儿童患肠胃炎的主要原因之一。对流行的 G 和 P 型轮状病毒基因型进行分析，对于评估全球儿童大规模接种疫苗的适宜性至关重要。本研究共采集了来自阿尔巴尼亚地拉那、意大利南部萨伦托半岛和罗马 3 家不同医院的 592 份粪便样本。在阿尔巴尼亚，总样本中有 31.3%为轮状病毒阳性，在萨伦托半岛为 78.3%，在罗马为 40.3%。在罗马和地拉那采集的样本进行了 G-P 分型，而在萨伦托半岛采集的样本仅进行了 G 型分型。总体而言，意大利最常见的组合为 G4 P[8]（54.5%）、G1 P[8]（27.3%）和 G2 P[4]（18.2%）；在阿尔巴尼亚则为 G9 P[8]（72.1%）、G4 P[8]（8.8%）、G1 P[8]（5.9%）和 G2 P[4]（2.9%）。G4 P[4]和 G9 P[4]的非典型组合在阿尔巴尼亚的流行率分别为 7.4%和 2.9%。本研究还进行了系统进化分析，以评估病毒株的遗传相关性。J. Med. Virol. 82:510-518, 2010. (c) 2010 Wiley-Liss, Inc.
