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针刺联合中药汤剂治疗代偿期肝硬化的疗效观察

[Observation on therapeutic effect of acupuncture combined with Chinese herbal decoction on compensated liver cirrhosis].

作者信息

Han Jie, Gu Ya-jiao

机构信息

The Second Department of Digestology, The First Affiliated Hospital of Henan College of TCM, Zhengzhou 450000, China.

出版信息

Zhongguo Zhen Jiu. 2009 Dec;29(12):970-2.

Abstract

OBJECTIVE

To compare the clinical effect difference between acupuncture combined with Chinese herb plus western medicine and simple western medicine in the treatment of compensated liver cirrhosis.

METHODS

Eighty cases were divided into a high viral load group and a low viral load group according to HBV-DNA test. The patients in two groups were randomly divided into a Chinese medicine plus western medicine treatment group (group A, group C) and a western medicine treatment group (Group B,group D), respectively, 20 cases in each group. The group A was treated with acupuncture at Ganshu (BL 18), Qimen (LR 14), Sanyinjiao (SP 6), etc. and oral administration of Chinese herbal decoction combined with Heptodin tablets; the group B with oral administration of Glucurolactone tablets combined with Heptodin tablets; the group C was treated with acupuncture at Ganshu (BL 18), Qimen (LR 14), Taixi (KI 3), etc. and oral administration of Chinese herbal decoction; the group D with oral administration of Glucurolactone tablets alone. After they were treated for 30 days, their therapeutic effects and the negative conversion rate of HBV-DNA were observed.

RESULTS

The total effective rate of 95.0% in the group A was better than 70.0% in the group B, and the total effective rate of 95.0% in the group C was better than 65.0% in the group D (both P < 0.05). There was no significant difference in the negative conversion rate of HBV-DNA between group A and group B or between group C and group D (both P > 0.05).

CONCLUSION

Acupuncture combined with Chinese herb plus western medicine treatment can more significantly improve clinical symptoms of the patients with compensated liver cirrhosis than simple western medicine therapy.

摘要

目的

比较针刺联合中药加西药与单纯西药治疗代偿期肝硬化的临床疗效差异。

方法

80例患者根据HBV-DNA检测分为高病毒载量组和低病毒载量组。两组患者再分别随机分为中西医结合治疗组(A组、C组)和西药治疗组(B组、D组),每组20例。A组采用针刺肝俞(BL 18)、期门(LR 14)、三阴交(SP 6)等穴位并口服中药汤剂联合和络舒肝片;B组口服葡醛内酯片联合和络舒肝片;C组采用针刺肝俞(BL 18)、期门(LR 14)、太溪(KI 3)等穴位并口服中药汤剂;D组仅口服葡醛内酯片。治疗30天后,观察其治疗效果及HBV-DNA阴转率。

结果

A组总有效率95.0%优于B组的70.0%,C组总有效率95.0%优于D组的65.0%(均P < 0.05)。A组与B组、C组与D组之间HBV-DNA阴转率差异无统计学意义(均P > 0.05)。

结论

针刺联合中药加西药治疗较单纯西药治疗能更显著改善代偿期肝硬化患者的临床症状。

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