印度西部马哈拉施特拉邦 HLA 等位基因与丙型肝炎感染的相关性。

Association of HLA alleles with hepatitis C infection in Maharashtra, western India.

机构信息

National Institute of Virology (ICMR), Pune, India.

出版信息

Indian J Med Res. 2009 Nov;130(5):550-5.

PMID:20090103

Abstract

BACKGROUND & OBJECTIVE: Host genetic diversity is believed to contribute to the spectrum of clinical outcomes in hepatitis C virus (HCV) infection. The present study aimed at finding out the frequencies of HLA class I and class II alleles of HCV infected individuals from western India.

METHODS

Forty three clinically characterized anti-HCV positive patients from Maharashtra were studied for HLA A, B, C, DRB1 and DQB1 alleles by PCR- sequence specific primer (SSP) typing method and compared with 67 and 113 ethnically matched, anti-HCV negative healthy controls from western India.

RESULTS

Our analysis revealed an association of HLA alleles HLA A03 (OR= 16.69, EF, 0.44, P=7.9E-12), A32 (OR= 1474, EF 0.21, P=1.8E-9), HLA B15 (OR=14.11, EF 0.39, P=2.18E-10), B55 (OR= 12.09, EF 0.07, P=0.005), Cw16 (OR= 7.45, EF 0.12, P=0.001), Cw18 (OR= 402, EF 0.05, P=0.003), DRB103 (OR= 4.01, EF 0.08, P=0.01) and DQB103 (OR= 3.02, EF 0.22, P=0.001), with HCV infection. HLA II locus haplotype DRB111-DQB103 (HF=17.64, OR=5.16, P=0.0001) was significantly increased among HCV infected individuals.

INTERPRETATION & CONCLUSION: Our data suggest that among the western Indian population, certain HLA alleles or associated haplotype influence HCV infection as a host genetic factor.

摘要

背景与目的

宿主遗传多样性被认为是导致丙型肝炎病毒（HCV）感染患者临床表现多样化的原因之一。本研究旨在探讨来自印度西部 HCV 感染患者的人类白细胞抗原（HLA）I 类和 II 类等位基因的频率。

方法

采用聚合酶链反应-序列特异性引物（PCR-SSP）方法，对来自马哈拉施特拉邦的 43 例具有临床特征的抗 HCV 阳性患者进行 HLA-A、B、C、DRB1 和 DQB1 等位基因分型，并与来自印度西部的 67 名和 113 名种族匹配的抗 HCV 阴性健康对照者进行比较。

结果

我们的分析显示，HLA 等位基因 HLA-A03（OR=16.69，EF，0.44，P=7.9E-12）、A32（OR=1474，EF 0.21，P=1.8E-9）、B15（OR=14.11，EF 0.39，P=2.18E-10）、B55（OR=12.09，EF 0.07，P=0.005）、Cw16（OR=7.45，EF 0.12，P=0.001）、Cw18（OR=402，EF 0.05，P=0.003）、DRB103（OR=4.01，EF 0.08，P=0.01）和 DQB103（OR=3.02，EF 0.22，P=0.001）与 HCV 感染相关。HLA II 基因座单体型 DRB111-DQB103（HF=17.64，OR=5.16，P=0.0001）在 HCV 感染患者中显著增加。