Lecture notes: 2010 and beyond, the decade of high-performance computing for the next-generation sequence analysis.

Effective analysis of the next-generation sequence relies on the intelligent algorithms for handling the meta-genome, epigenetic and disease genome, as well as immune-genome, viral profiling, transcriptome profiling, and de novo genome sequencing data, therefore, next-generation sequence analysis is a very important but challenging task in bioinformatics due to extremely large-scale 'noisy' datasets. We focus mainly on the development of high-performance genetic algorithms based on multi-core technology as an example and open to fast-moving competing platforms to be emerged.