使用来自厌氧菌的还原酶通过短的化学酶法途径制备手性β-芳基-γ-氨基酸。
A short, chemoenzymatic route to chiral beta-aryl-gamma-amino acids using reductases from anaerobic bacteria.
机构信息
Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, United Kingdom.
出版信息
Org Biomol Chem. 2010 Feb 7;8(3):533-5. doi: 10.1039/b919526b. Epub 2009 Nov 10.
DOI:10.1039/b919526b
PMID:20090967
Abstract
A short chemoenzymatic synthesis of beta-aryl-gamma-aminobutyric acids has been developed, based on a highly enantioselective biocatalytic reduction of beta-aryl-beta-cyano-alpha,beta-unsaturated carboxylic acids.
摘要
已经开发出一种基于β-芳基-β-氰基-α，β-不饱和羧酸的高度对映选择性生物催化还原的β-芳基-γ-氨基丁酸的短的化学酶法合成。
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