Loss of membrane protein thiols and lipid peroxidation in allyl alcohol hepatotoxicity.
作者信息
Pompella A, Romani A, Benedetti A, Comporti M
机构信息
Istituto di Patologia Generale dell'Università di Siena, Italy.
出版信息
Biochem Pharmacol. 1991 Apr 15;41(8):1255-9. doi: 10.1016/0006-2952(91)90666-s.
PMID:2009100
Abstract
The data reported suggest that--following initiation of lipid peroxidation--membrane protein thiols can be attacked by lipid-derived radicals and/or reactive, lipid-soluble aldehydes like 4-hydroxynonenal and other hydroxyalkenals originated within the lipid core of cell membranes, resulting in a membrane protein thiol loss which is in turn associated with the development of hepatocellular injury.
摘要
Zotero 插件