Cirocchi Roberto, Abraha Iosief, Montedori Alessandro, Farinella Eriberto, Bonacini Isabella, Tagliabue Ludovica, Sciannameo Francesco
Clinica Chirurgica Generale e d'Urgenza, Azienda Ospedaliera di Terni, Terni, Italy, 05100.
Cochrane Database Syst Rev. 2010 Jan 20(1):CD007438. doi: 10.1002/14651858.CD007438.pub2.
Trauma is one of the leading causes of death in any age group. The 'lethal triad' of acidosis, hypothermia, and coagulopathy has been recognized as a significant cause of death in patients with traumatic injuries. In order to prevent the lethal triad two factors are essential, early control of bleeding and prevention of further heat loss. In patients with major abdominal trauma, damage control surgery (DCS) avoids extensive procedures on unstable patients, stabilizes potentially fatal problems at initial operation, and applies staged surgery after successful initial resuscitation. It is not currently known whether DCS is superior to immediate surgery for patients with major abdominal trauma.
To assess the effectiveness of DCS compared to traditional immediate definitive surgical treatment for patients with major abdominal trauma.
We searched the Cochrane Injuries Group Specialised Register, CENTRAL (The Cochrane Library 2008, Issue 3), MEDLINE, EMBASE, Web of Science: Science Citation Index & ISI Proceedings, Current Controlled Trials MetaRegister, Clinicaltrials.gov, Zetoc, and CINAHL for all published and unpublished randomised controlled trials. We did not restrict the searches by language, date, or publication status. Searches were conducted in August 2008.
Randomised controlled trials of DCS versus immediate traditional surgical repair were included in this review. We included patients with major abdominal trauma (Abbreviated Injury Scale > 3) who were undergoing surgery. Patient selection was crucial as patients with relatively simple abdominal injuries should not undergo unnecessary procedures.
Two authors independently evaluated the search results.
A total of 1523 studies were identified by our search. No randomised controlled trials comparing DCS with immediate and definitive repair in patients with major abdominal trauma were found. A total of 1521 studies were excluded because they were not relevant to the review topic and two studies were excluded because they were case-control studies.
AUTHORS' CONCLUSIONS: Evidence that supports the efficacy of DCS with respect to traditional laparotomy in patients with major abdominal trauma is limited.
创伤是各年龄组主要的死亡原因之一。酸中毒、体温过低和凝血功能障碍的“致死三联征”已被公认为创伤患者死亡的重要原因。为预防致死三联征,两个因素至关重要,即早期控制出血和防止进一步热量散失。在严重腹部创伤患者中,损伤控制手术(DCS)避免了对不稳定患者进行广泛手术,在初次手术时稳定潜在致命问题,并在初次复苏成功后进行分期手术。目前尚不清楚DCS对于严重腹部创伤患者是否优于即刻手术。
评估与传统即刻确定性手术治疗相比,DCS对严重腹部创伤患者的有效性。
我们检索了Cochrane损伤组专业注册库、CENTRAL(Cochrane图书馆2008年第3期)、MEDLINE、EMBASE、科学网:科学引文索引及ISI会议录、当前对照试验Meta注册库、Clinicaltrials.gov、Zetoc和护理学与健康领域数据库,以查找所有已发表和未发表的随机对照试验。我们未对检索进行语言、日期或出版状态限制。检索于2008年8月进行。
本综述纳入DCS与即刻传统手术修复对比的随机对照试验。我们纳入了正在接受手术的严重腹部创伤患者(简明损伤定级>3)。患者选择至关重要,因为腹部损伤相对简单的患者不应接受不必要的手术。
两位作者独立评估检索结果。
我们的检索共识别出1523项研究。未发现比较DCS与严重腹部创伤患者即刻确定性修复的随机对照试验。共排除1521项研究,因为它们与综述主题无关,另外两项研究因属于病例对照研究而被排除。
支持DCS在严重腹部创伤患者中相对于传统剖腹术疗效的证据有限。