没食子酸 3,4-二羟基苯乙基酯的合成与生物评价。
Synthesis and biological evaluation of caffeic acid 3,4-dihydroxyphenethyl ester.
机构信息
Jiangxi Doctors Science and Technology R&D Co., Ltd., Nanchang 330029, People's Republic of China.
出版信息
J Nat Prod. 2010 Feb 26;73(2):252-4. doi: 10.1021/np900519d.
PMID:20092326
Abstract
A high-yield synthesis of caffeic acid 3,4-dihydroxyphenethyl ester (1) has been achieved through Knoevenagel condensation of 3,4-dihydroxybenzaldehyde and 3,4-dihydroxyphenethyl monomalonate as the key step. Compound 1 was tested against a 56-cell-line cytotoxicity panel and for its free-radical-scavenging activity in the DPPH test.
摘要
通过 3,4-二羟基苯甲醛和 3,4-二羟基苯乙基丙二酸单酯的 Knoevenagel 缩合作为关键步骤，实现了咖啡酸 3,4-二羟苯乙基酯（1）的高产合成。化合物 1 进行了 56 细胞系细胞毒性筛选，并在 DPPH 试验中测试了其自由基清除活性。
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