Bai Xuelian, Sheng Yue, Tang Zhenxing, Pan Jingyi, Wang Shigui, Tang Bin, Zhou Ting, Shi Lu'e, Zhang Huawei
College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 311121, China.
School of Culinary Arts, Tourism College of Zhejiang, Hangzhou 311231, China.
J Fungi (Basel). 2023 Feb 15;9(2):261. doi: 10.3390/jof9020261.
Polyketides are an important class of structurally diverse natural products derived from a precursor molecule consisting of a chain of alternating ketone and methylene groups. These compounds have attracted the worldwide attention of pharmaceutical researchers since they are endowed with a wide array of biological properties. As one of the most common filamentous fungi in nature, spp. is well known as an excellent producer of polyketide compounds with therapeutic potential. By extensive literature search and data analysis, this review comprehensively summarizes -derived polyketides for the first time, regarding their occurrences, chemical structures and bioactivities as well as biosynthetic logics.
聚酮化合物是一类重要的天然产物,其结构多样,来源于由酮基和亚甲基交替组成的链状前体分子。这些化合物因其具有广泛的生物学特性而吸引了全球药物研究人员的关注。作为自然界中最常见的丝状真菌之一,[具体菌种名称]被公认为是具有治疗潜力的聚酮化合物的优秀生产者。通过广泛的文献检索和数据分析,本综述首次全面总结了[具体菌种名称]产生的聚酮化合物,包括它们的存在情况、化学结构、生物活性以及生物合成逻辑。