一种印度尼西亚链霉菌来源的修饰苯并嗪类化合物
Modified phenazines from an Indonesian Streptomyces sp.
机构信息
Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331-3507, USA.
出版信息
J Nat Prod. 2010 Mar 26;73(3):472-5. doi: 10.1021/np9005647.
Abstract
Fractionation of the extract from the Indonesian Streptomyces sp. ICBB8198 as directed by the antibacterial activity delivered the known phenazine antibiotics griseoluteic acid (1a) and griseolutein A (1b), as well as two new phenazine derivatives (2 and 3). In addition, the known compounds spirodionic acid, dihydrosarkomycins, and 6-ethyl-4-hydroxy-3,5-dimethyl-2H-pyran-2-one (4a), along with the new pyrone 3,6-diethyl-4-hydroxy-5-methyl-2H-pyran-2-one (4b), were isolated. We report here the isolation, structure elucidation, and antibiotic activity of the new metabolites as well as a hypothetical pathway for the formation of the new phenazine derivatives.
摘要
根据抗菌活性的指示，对印度尼西亚链霉菌 ICBB8198 的提取物进行分段提取，得到了已知的吩嗪类抗生素灰绿酸（1a）和灰绿菌素 A（1b），以及两种新的吩嗪衍生物（2 和 3）。此外，还分离得到了已知化合物螺二酮酸、二氢沙克菌素和 6-乙基-4-羟基-3,5-二甲基-2H-吡喃-2-酮（4a），以及新的吡喃酮 3,6-二乙基-4-羟基-5-甲基-2H-吡喃-2-酮（4b）。我们在这里报告了新代谢物的分离、结构阐明和抗生素活性，以及新吩嗪衍生物形成的假设途径。
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