来自印度尼西亚链霉菌属的重排和未重排的安古环素类化合物

Rearranged and unrearranged angucyclinones from Indonesian Streptomyces spp.

作者信息

Fotso Serge, Mahmud Taifo, Zabriskie T Mark, Santosa Dwi Andreas, Proteau Philip J

机构信息

Department of Pharmaceutical Sciences, College of Pharmacy, Corvallis, Oregon 97331-3507, USA.

出版信息

J Antibiot (Tokyo). 2008 Jul;61(7):449-56. doi: 10.1038/ja.2008.61.

DOI:10.1038/ja.2008.61

PMID:18776657

Abstract

Two Indonesian Streptomyces strains, ICBB8309 and ICBB8415, were investigated for their ability to produce antibiotic compounds. In addition to the known antibiotics actiphenol, naramycin B, and sabaramycin, six new angucyclinones were identified. The isolation, structure elucidation and biological activities for the six new compounds are presented. The angucyclinones 7-deoxo-6-deoxy-7-hydroxy-8-O-methylrabelomycin, 1-deoxo-1-hydroxy-8-O-methylrabelomycin, and the angucycline 7-deoxo-7-hydroxy-1-O-alpha-rhamnosyl-8-O-methyltetrangulol have common angular backbones, while angucyclinone C, limamycin A, and limamycin B appear to be rearranged angucyclinones.

摘要

对两株印度尼西亚链霉菌菌株ICBB8309和ICBB8415产生抗生素化合物的能力进行了研究。除了已知的抗生素阿替酚、纳拉霉素B和萨巴拉霉素外，还鉴定出六种新的安古环素类化合物。介绍了这六种新化合物的分离、结构解析和生物活性。安古环素类化合物7-脱氧-6-脱氧-7-羟基-8-O-甲基拉贝洛霉素、1-脱氧-1-羟基-8-O-甲基拉贝洛霉素以及安古环素7-脱氧-7-羟基-1-O-α-鼠李糖基-8-O-甲基四方苦醇具有共同的角状骨架，而安古环素C、利马霉素A和利马霉素B似乎是重排的安古环素类化合物。